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Medin amyloid may drive arterial aging and disease in the periphery and brain.

作者信息

Madine Jillian, Davies Hannah A, Migrino Raymond Q, Ruotsalainen Sanni E, Wagner Jessica, Neher Jonas J

机构信息

Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

Phoenix Veterans Affairs Health Care System and University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.

出版信息

Nat Aging. 2023 Sep;3(9):1039-1041. doi: 10.1038/s43587-023-00481-3.

DOI:10.1038/s43587-023-00481-3
PMID:37620584
Abstract
摘要

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Medin amyloid may drive arterial aging and disease in the periphery and brain.Medin淀粉样蛋白可能会促使外周和大脑的动脉衰老及病变。
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2
Computational insights into the cross-talk between medin and Aβ: implications for age-related vascular risk factors in Alzheimer's disease.对medin与β-淀粉样蛋白之间相互作用的计算洞察：对阿尔茨海默病中与年龄相关的血管危险因素的影响
Brief Bioinform. 2024 Jan 22;25(2). doi: 10.1093/bib/bbad526.
3
Medin-amyloid: a recently characterized age-associated arterial amyloid form affects mainly arteries in the upper part of the body.Medin淀粉样蛋白：一种最近被鉴定出的与年龄相关的动脉淀粉样蛋白形式，主要影响身体上部的动脉。
Amyloid. 2005 Jun;12(2):96-102. doi: 10.1080/13506120500107006.
4
Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside-Containing Nanoliposomes.mediin 介导的内皮免疫激活：在脑血管疾病中的潜在作用及其被含神经节苷脂的纳米脂质体逆转。
J Am Heart Assoc. 2020 Jan 21;9(2):e014810. doi: 10.1161/JAHA.119.014810. Epub 2020 Jan 13.
5
Transcriptomic analyses reveal proinflammatory activation of human brain microvascular endothelial cells by aging-associated peptide medin and reversal by nanoliposomes.转录组分析揭示了衰老相关肽 medin 对人脑血管内皮细胞的促炎激活作用，而纳米脂质体则可逆转这一作用。
Sci Rep. 2023 Nov 1;13(1):18802. doi: 10.1038/s41598-023-45959-7.
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Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia.脑血管介质与阿尔茨海默病和血管性痴呆有关。
Alzheimers Dement (Amst). 2020 Aug 25;12(1):e12072. doi: 10.1002/dad2.12072. eCollection 2020.
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Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice.髓系细胞聚集导致衰老野生型小鼠脑血管功能障碍。
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23925-23931. doi: 10.1073/pnas.2011133117. Epub 2020 Sep 8.
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Medin and medin-amyloid in ageing inflamed and non-inflamed temporal arteries.衰老的炎症性和非炎症性颞动脉中的Medin和Medin淀粉样蛋白
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Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin.比较聚集增强和抑制作为降低主动脉淀粉样多肽 medin 细胞毒性的策略。
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Lactadherin binds to elastin--a starting point for medin amyloid formation?乳黏附素与弹性蛋白结合——这是髓核淀粉样蛋白形成的起始点吗？
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Computational insights into the aggregation mechanism and amyloidogenic core of aortic amyloid medin polypeptide.计算洞察主动脉淀粉样 medin 多肽的聚集机制和淀粉样形成核心。
Colloids Surf B Biointerfaces. 2024 Dec;244:114192. doi: 10.1016/j.colsurfb.2024.114192. Epub 2024 Aug 30.
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Investigating Medin Cleavage Accessibility in MfgE8: Conformational Insights Derived from Molecular Dynamics Simulations and AlphaFold2 Models.

本文引用的文献

1
Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization.血管平滑肌细胞衰老通过小细胞外囊泡分泌和细胞外基质重排加速 medin 聚集。
Aging Cell. 2023 Feb;22(2):e13746. doi: 10.1111/acel.13746. Epub 2022 Nov 25.
2
Medin co-aggregates with vascular amyloid-β in Alzheimer's disease.在阿尔茨海默病中，Medin 与血管淀粉样-β共同聚集。
Nature. 2022 Dec;612(7938):123-131. doi: 10.1038/s41586-022-05440-3. Epub 2022 Nov 16.
3
Genetic risk factors have a substantial impact on healthy life years.
研究MfgE8中Medin的切割可及性：源自分子动力学模拟和AlphaFold2模型的构象见解
bioRxiv. 2024 Jul 29:2024.07.27.605412. doi: 10.1101/2024.07.27.605412.
4
Computational insights into the cross-talk between medin and Aβ: implications for age-related vascular risk factors in Alzheimer's disease.对medin与β-淀粉样蛋白之间相互作用的计算洞察：对阿尔茨海默病中与年龄相关的血管危险因素的影响
Brief Bioinform. 2024 Jan 22;25(2). doi: 10.1093/bib/bbad526.
遗传风险因素对健康寿命有重大影响。
Nat Med. 2022 Sep;28(9):1893-1901. doi: 10.1038/s41591-022-01957-2. Epub 2022 Sep 12.
4
Inflammatory Role of Milk Fat Globule-Epidermal Growth Factor VIII in Age-Associated Arterial Remodeling.牛奶脂肪球-表皮生长因子 VIII 在与年龄相关的动脉重塑中的炎症作用。
J Am Heart Assoc. 2022 Sep 6;11(17):e022574. doi: 10.1161/JAHA.121.022574. Epub 2022 Aug 24.
5
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis.MFGE8 基因框内插入和剪接位点变异与冠状动脉粥样硬化保护相关。
Commun Biol. 2022 Aug 17;5(1):802. doi: 10.1038/s42003-022-03552-0.
6
Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice.髓系细胞聚集导致衰老野生型小鼠脑血管功能障碍。
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23925-23931. doi: 10.1073/pnas.2011133117. Epub 2020 Sep 8.
7
Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside-Containing Nanoliposomes.mediin 介导的内皮免疫激活：在脑血管疾病中的潜在作用及其被含神经节苷脂的纳米脂质体逆转。
J Am Heart Assoc. 2020 Jan 21;9(2):e014810. doi: 10.1161/JAHA.119.014810. Epub 2020 Jan 13.
8
Idiopathic degenerative thoracic aneurysms are associated with increased aortic medial amyloid.特发性退行性胸主动脉瘤与主动脉中层淀粉样变性有关。
Amyloid. 2019 Sep;26(3):148-155. doi: 10.1080/13506129.2019.1625323. Epub 2019 Jun 18.
9
Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementia.正常人认知、轻度认知障碍和痴呆患者的大脑侧支小动脉功能。
Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H284-H290. doi: 10.1152/ajpheart.00206.2018. Epub 2018 May 18.
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Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid.氧化应激改变主动脉中层淀粉样蛋白的形态和毒性。
Biophys J. 2015 Dec 1;109(11):2363-70. doi: 10.1016/j.bpj.2015.10.034.