Orthopedics Department, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.
Orthop Surg. 2023 Nov;15(11):2749-2765. doi: 10.1111/os.13848. Epub 2023 Aug 24.
Osteoarthritis (OA) causes disability and significant economic and social burden. Cartilage injury is one of the main pathological features of OA, and is often manifested by excessive chondrocyte death, inflammatory response, abnormal bone metabolism, imbalance of extracellular matrix (ECM) metabolism, and abnormal vascular or nerve growth. Regrettably, due to the avascular nature of cartilage, its capacity to repair is notably limited. Mesenchymal stem cells-derived extracellular vesicles (MSCs-EVs) play a pivotal role in intercellular communication, presenting promising potential not only as early diagnostic biomarkers in OA but also as efficacious therapeutic strategy. MSCs-EVs were confirmed to play a therapeutic role in the pathological process of cartilage injury mentioned above. This paper comprehensively provides the functions and mechanisms of MSCs-EVs in cartilage repair.
骨关节炎（OA）导致残疾，给经济和社会带来重大负担。软骨损伤是 OA 的主要病理特征之一，常表现为软骨细胞过度死亡、炎症反应、异常骨代谢、细胞外基质（ECM）代谢失衡以及异常血管或神经生长。遗憾的是，由于软骨的无血管特性，其修复能力明显受限。间充质干细胞衍生的细胞外囊泡（MSCs-EVs）在细胞间通讯中发挥着关键作用，不仅有望成为 OA 的早期诊断生物标志物，而且可能成为有效的治疗策略。MSCs-EVs 已被证实可在上述软骨损伤的病理过程中发挥治疗作用。本文全面阐述了 MSCs-EVs 在软骨修复中的作用和机制。
