Wang Xiaofei, Xu Lei, Wu Zhimin, Lou Linbing, Xia Cunyi, Miao Haixiang, Dai Jihang, Fei Wenyong, Wang Jingcheng
The Graduate School, Dalian Medical University, Dalian 116044, China.
Department of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou 225001, China.
Precis Clin Med. 2024 Nov 26;8(1):pbae032. doi: 10.1093/pcmedi/pbae032. eCollection 2025 Mar.
The aging population has led to a global issue of osteoarthritis (OA), which not only impacts the quality of life for patients but also poses a significant economic burden on society. While biotherapy offers hope for OA treatment, currently available treatments are unable to delay or prevent the onset or progression of OA. Recent studies have shown that as nanoscale bioactive substances that mediate cell communication, exosomes from stem cell sources have led to some breakthroughs in the treatment of OA and have important clinical significance. This paper summarizes the mechanism and function of stem cell exosomes in delaying OA and looks forward to the development prospects and challenges of exosomes.
人口老龄化导致了骨关节炎（OA）这一全球性问题，它不仅影响患者的生活质量，还对社会造成了巨大的经济负担。虽然生物疗法为OA治疗带来了希望，但目前可用的治疗方法无法延缓或预防OA的发作或进展。最近的研究表明，作为介导细胞通讯的纳米级生物活性物质，干细胞来源的外泌体在OA治疗中取得了一些突破，具有重要的临床意义。本文总结了干细胞外泌体在延缓OA方面的作用机制，并展望了外泌体的发展前景与挑战。
