IVF unit, Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Jerusalem, Israel.
Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Reprod Biol Endocrinol. 2023 Aug 24;21(1):77. doi: 10.1186/s12958-023-01122-5.
Clinicians involved in fertility preservation (FP) are often required to make prompt and consequential decisions despite the absence of evidence-based data. We established a collaborative professional online consultation group for fertility preservation issues. We sought to determine the main controversial clinical issues in FP as raised by participants of this group.
Content analysis of a dedicated community of practice interacting via a messaging application (WhatsApp) and a survey of group participants.
Between January 2019 and July 2022, group members posed 39 clinical questions which were discussed and debated by the group. Common themes included management of oncofertility cases (33%), potential gonadotoxicity of various therapies (23%), fertility preservation in women and girls with premature ovarian insufficiency (POI) (18%), and technical aspects of ovarian tissue cryopreservation (10%). All but one query received prompt response (mean time for first response for 95% of queries 7.1 ± 9.0 min) from a mean of 5.4 ± 3.2 members. An anonymous online survey of group members was conducted during August 2022 (n = 31, response rate 94%). The majority of respondents stated they gained knowledge and assistance in clinical decision making from participation in the discussion group (90% and 58% of respondents, respectively).
Management of clinical oncofertility cases, potential gonadotoxic effect of therapeutics and fertility preservation in women and girls with POI were the most common controversial issues in our fertility preservation community of practice. Intra-professional collaborative communication via a messaging application can aid in clinical management of fertility preservation and augment clinician's knowledge.
尽管缺乏基于证据的数据，但参与生育力保存（FP）的临床医生经常需要做出迅速而重要的决策。我们成立了一个专门的生育力保存问题在线协作专业咨询小组。我们旨在确定该小组参与者提出的 FP 中主要的有争议的临床问题。
通过消息应用程序（WhatsApp）进行协作的实践社区的内容分析，以及对小组成员的调查。
在 2019 年 1 月至 2022 年 7 月期间，小组成员提出了 39 个临床问题，这些问题由小组进行了讨论和辩论。常见的主题包括癌症生育力管理（33%）、各种治疗方法的潜在性腺毒性（23%）、患有卵巢早衰（POI）的女性和女孩的生育力保存（18%），以及卵巢组织冷冻保存的技术方面（10%）。除了一个查询之外，所有查询都得到了快速响应（95%的查询的第一个响应的平均时间为 7.1±9.0 分钟），平均有 5.4±3.2 名成员做出响应。在 2022 年 8 月期间对小组成员进行了匿名在线调查（n=31，响应率为 94%）。大多数受访者表示，他们从参与讨论小组中获得了知识和临床决策帮助（分别为 90%和 58%的受访者）。
癌症生育力管理、治疗的潜在性腺毒性作用以及 POI 女性和女孩的生育力保存是我们生育力保存实践社区中最常见的有争议问题。通过消息应用程序进行的专业内部协作沟通可以帮助进行生育力保存的临床管理，并增加临床医生的知识。
