Nagao Masanori, Matsumoto Hikaru, Miura Yoshiko
Chemical Engineering, Kyushu University, Motooka 744, Nishi-ku Fukuoka, Japan.
Chem Asian J. 2023 Oct 4;18(19):e202300643. doi: 10.1002/asia.202300643. Epub 2023 Sep 4.
Carbohydrates are involved in life activities through the interactions with their corresponding proteins (lectins). Pathogen infection and the regulation of cell activity are controlled by the binding between lectins and glycoconjugates on cell surfaces. A deeper understanding of the interactions of glycoconjugates has led to the development of therapeutic and preventive methods for infectious diseases. Glycopolymer is one of the classes of the materials present multiple carbohydrates. The properties of glycopolymers can be tuned through the molecular design of the polymer structures. This review focuses on research over the past decade on the design of glycopolymers with the aim of developing inhibitors against pathogens and manipulator of cellular functions.
碳水化合物通过与相应蛋白质（凝集素）的相互作用参与生命活动。病原体感染和细胞活性的调节由凝集素与细胞表面糖缀合物之间的结合控制。对糖缀合物相互作用的更深入理解导致了传染病治疗和预防方法的发展。糖聚合物是呈现多种碳水化合物的材料类别之一。糖聚合物的性质可以通过聚合物结构的分子设计来调节。本综述重点关注过去十年中关于糖聚合物设计的研究，目的是开发针对病原体的抑制剂和细胞功能的操纵剂。
