M'Buyamba-Kabangu J R, Lijnen P, Fagard R, Amery A
Methods Find Exp Clin Pharmacol. 1986 Jul;8(7):437-42.
Blood pressure and intraerythrocyte sodium and potassium concentration were investigated in 59 male inhabitants of an urban quarter of Kinshasa, aged 10 years and older. Two subjects were excluded because they were on antihypertensive treatment. Seventeen subjects were normotensive with both parents normotensive (group 1); 9 subjects were normotensive with at least one hypertensive parent (group 2); 5 subjects were untreated hypertensives (group 3) and 26 subjects could not be classified (group 4). Systolic pressure and intraerythrocyte sodium concentration (expressed in mmol/1 cells) were significantly higher in normotensive subjects with a positive family history of hypertension (group 2) than in normotensive males of comparable age, weight and height, born to normotensive parents (group 1). Untreated hypertensives (group 3) were older and their intraerythrocyte sodium concentration was higher in comparison to normotensives without positive family history of hypertension. The intraerythrocyte potassium concentration did not differ significantly among groups 1, 2 and 3. When the first three groups of participants, or all the subjects with the exclusion of treated hypertensives, were considered, no relationship could be demonstrated between the level of blood pressure and the intraerythrocyte sodium and potassium concentration. It can be concluded that parental hypertension in normotensive African blacks is associated with increased intraerythrocyte sodium concentration.
对金沙萨一个城区59名年龄在10岁及以上的男性居民的血压以及红细胞内钠和钾浓度进行了调查。两名受试者因正在接受抗高血压治疗而被排除。17名受试者血压正常且父母均血压正常（第1组）；9名受试者血压正常但至少有一位高血压父母（第2组）；5名受试者为未经治疗的高血压患者（第3组）；26名受试者无法分类（第4组）。有高血压家族史的血压正常受试者（第2组）的收缩压和红细胞内钠浓度（以mmol/1细胞表示）显著高于父母血压正常、年龄、体重和身高相当的血压正常男性（第1组）。未经治疗的高血压患者（第3组）年龄更大，与无高血压家族史的血压正常者相比，其红细胞内钠浓度更高。第1、2和3组之间的红细胞内钾浓度没有显著差异。当考虑前三组参与者，或排除接受治疗的高血压患者后的所有受试者时，血压水平与红细胞内钠和钾浓度之间未显示出相关性。可以得出结论，血压正常的非洲黑人中，父母患高血压与红细胞内钠浓度升高有关。
