Myers J B, Morgan T O, Edwards K
Clin Exp Pharmacol Physiol. 1983 May-Jun;10(3):361-4. doi: 10.1111/j.1440-1681.1983.tb00213.x.
The effect of changing sodium intake for 2 weeks was studied. Twelve normotensive subjects and five patients with mild essential hypertension were given two different levels of sodium intake for 2 weeks. Overall there was no significant rise in blood pressure but all patients with hypertension had a rise in blood pressure as they went from a low to a high sodium intake. Plasma sodium was not altered but red cell sodium concentration was higher on the high sodium intake. This effect was observed in both normotensive and hypertensive people. Alterations observed in cell sodium concentration provide support for the hypothesis that increased dietary intake of sodium may induce hypertension by causing changes in cellular transport systems.
研究了钠摄入量改变两周的效果。12名血压正常的受试者和5名轻度原发性高血压患者被给予两种不同水平的钠摄入量，为期两周。总体而言，血压没有显著升高，但所有高血压患者在从低钠摄入量转变为高钠摄入量时血压都有所升高。血浆钠未发生改变，但高钠摄入量时红细胞钠浓度更高。在血压正常者和高血压患者中均观察到了这种效应。细胞钠浓度的变化为以下假说提供了支持：即增加钠的饮食摄入量可能通过引起细胞转运系统的变化而诱发高血压。
