College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang 455000, China.
Henan Key Laboratory of Biomolecular Recognition and Sensing, Shangqiu Normal University, Shangqiu 476000, China.
Biosensors (Basel). 2023 Aug 3;13(8):785. doi: 10.3390/bios13080785.
It is of great importance to have sensitive and accurate detection of -diol-containing biologically related substances because of their important functions in the research fields of metabolomics, glycomics, and proteomics. Boronic acids can specifically and reversibly interact with 1,2- or 1,3-diols to form five or six cyclic esters. Based on this unique property, boronic acid-based materials have been used as synthetic receptors for the specific recognition and detection of -diol-containing species. This review critically summarizes the recent advances with boronic acid-based materials as recognition elements and signal labels for the detection of -diol-containing biological species, including ribonucleic acids, glycans, glycoproteins, bacteria, exosomes, and tumor cells. We also address the challenges and future perspectives for developing versatile boronic acid-based materials with various promising applications.
由于 -二醇类生物相关物质在代谢组学、糖组学和蛋白质组学研究领域中的重要功能，对其进行敏感、准确的检测显得尤为重要。硼酸可以特异性地、可逆地与 1,2-或 1,3-二醇相互作用，形成五或六元环酯。基于这一独特的性质，硼酸基材料已被用作合成受体，用于特异性识别和检测含 -二醇的物质。本综述批判性地总结了硼酸基材料作为识别元件和信号标记物，用于检测含 -二醇的生物物质，包括核糖核酸、聚糖、糖蛋白、细菌、外泌体和肿瘤细胞的最新进展。我们还讨论了开发具有各种有前途应用的多功能硼酸基材料所面临的挑战和未来展望。
