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聚醚醚酮(PEEK)及其在颅骨重建中的3D打印定量评估

Polyether-Ether-Ketone (PEEK) and Its 3D-Printed Quantitate Assessment in Cranial Reconstruction.

作者信息

Moiduddin Khaja, Mian Syed Hammad, Elseufy Sherif Mohammed, Alkhalefah Hisham, Ramalingam Sundar, Sayeed Abdul

机构信息

Advanced Manufacturing Institute, King Saud University, Riyadh 11421, Saudi Arabia.

Department of Oral and Maxillofacial Surgery, College of Dentistry and Dental University Hospital, King Saud University Medical City, Riyadh 11545, Saudi Arabia.

出版信息

J Funct Biomater. 2023 Aug 17;14(8):429. doi: 10.3390/jfb14080429.

Abstract

Three-dimensional (3D) printing, medical imaging, and implant design have all advanced significantly in recent years, and these developments may change how modern craniomaxillofacial surgeons use patient data to create tailored treatments. Polyether-ether-ketone (PEEK) is often seen as an attractive option over metal biomaterials in medical uses, but a solid PEEK implant often leads to poor osseointegration and clinical failure. Therefore, the objective of this study is to demonstrate the quantitative assessment of a custom porous PEEK implant for cranial reconstruction and to evaluate its fitting accuracy. The research proposes an efficient process for designing, fabricating, simulating, and inspecting a customized porous PEEK implant. In this study, a CT scan is utilized in conjunction with a mirrored reconstruction technique to produce a skull implant. In order to foster cell proliferation, the implant is modified into a porous structure. The implant's strength and stability are examined using finite element analysis. Fused filament fabrication (FFF) is utilized to fabricate the porous PEEK implants, and 3D scanning is used to test its fitting accuracy. The results of the biomechanical analysis indicate that the highest stress observed was approximately 61.92 MPa, which is comparatively low when compared with the yield strength and tensile strength of the material. The implant fitting analysis demonstrates that the implant's variance from the normal skull is less than 0.4436 mm, which is rather low given the delicate anatomy of the area. The results of the study demonstrate the implant's endurance while also increasing the patient's cosmetic value.

摘要

近年来,三维(3D)打印、医学成像和植入物设计都取得了显著进展,这些进展可能会改变现代颅颌面外科医生利用患者数据制定个性化治疗方案的方式。在医疗用途中,聚醚醚酮(PEEK)通常被视为比金属生物材料更具吸引力的选择,但实心PEEK植入物往往会导致骨整合不良和临床失败。因此,本研究的目的是展示对定制多孔PEEK颅骨重建植入物的定量评估,并评估其贴合精度。该研究提出了一种设计、制造、模拟和检查定制多孔PEEK植入物的有效流程。在本研究中,结合镜像重建技术利用CT扫描来制作颅骨植入物。为了促进细胞增殖,将植入物修改为多孔结构。使用有限元分析来检查植入物的强度和稳定性。利用熔融沉积成型(FFF)来制造多孔PEEK植入物,并使用3D扫描来测试其贴合精度。生物力学分析结果表明,观察到的最高应力约为61.92MPa,与材料的屈服强度和拉伸强度相比相对较低。植入物贴合分析表明,植入物与正常颅骨的差异小于0.4436mm,鉴于该区域精细的解剖结构,这一数值相当低。研究结果证明了植入物的耐久性,同时也提高了患者的美观度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be58/10455463/f8ca0e68b3f8/jfb-14-00429-g001.jpg

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