Traoré Afsatou Ndama, Rikhotso Mpumelelo Casper, Mphaphuli Marry Avheani, Patel Sana Mustakahmed, Mahamud Hafsa Ali, Kachienga Leonard Owino, Kabue Jean-Pierre, Potgieter Natasha
Department of Biochemistry and Microbiology, Faculty of Sciences, Engineering & Agriculture, University of Venda, Thohoyandou 0950, South Africa.
Pathogens. 2023 Aug 4;12(8):1015. doi: 10.3390/pathogens12081015.
Tuberculosis (TB), caused by (), remains a significant global health issue, with high morbidity and mortality rates. The emergence of drug-resistant strains, particularly multidrug-resistant TB (MDR-TB), poses difficult challenges to TB control efforts. This comprehensive review and meta-analysis investigated the prevalence of and molecular insights into isoniazid (INH) and rifampicin (RIF) resistance-conferring mutations in isolates from South Africa. Through systematic search and analysis of 11 relevant studies, we determined the prevalence of gene mutations associated with RIF and INH resistance, such as rpoB, katG, and inhA. The findings demonstrated a high prevalence of specific mutations, including S450L in rpoB, and S315T, which are linked to resistance against RIF and INH, respectively. These results contribute to the understanding of drug resistance mechanisms and provide valuable insights for the development of targeted interventions against drug-resistant TB.
由（）引起的结核病（TB）仍然是一个重大的全球健康问题，发病率和死亡率都很高。耐药菌株的出现，尤其是耐多药结核病（MDR-TB），给结核病控制工作带来了严峻挑战。这项全面的综述和荟萃分析调查了南非分离株中赋予异烟肼（INH）和利福平（RIF）耐药性的突变的流行情况及其分子见解。通过对11项相关研究的系统检索和分析，我们确定了与RIF和INH耐药性相关的基因突变的流行情况，如rpoB、katG和inhA。研究结果表明特定突变的高流行率，包括rpoB中的S450L以及分别与对RIF和INH耐药性相关的S315T。这些结果有助于理解耐药机制，并为开发针对耐药结核病的靶向干预措施提供有价值的见解。
