Department for Molecular & Medical Virology, Ruhr University Bochum, Bochum, Germany.
Institute for Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany.
J Hosp Infect. 2023 Nov;141:25-32. doi: 10.1016/j.jhin.2023.08.009. Epub 2023 Aug 23.
Respiratory syncytial virus (RSV) is known as a major cause of respiratory tract infection in adults and children. Human-to-human transmission occurs via droplets as well as direct and indirect contact (e.g. contaminated surfaces or hands of medical staff). Therefore, applicable hygiene measures and knowledge about viral inactivation are of utmost importance.
To elucidate the disinfection profile of RSV.
The study evaluated the virucidal efficacy of oral rinses specifically designed for children, World Health Organization (WHO)-recommended hand-rub formulations, and ethanol, as well as 2-propanol against RSV in a quantitative suspension test (EN14476). The stability of RSV on stainless steel discs was assessed and its inactivation by different surface disinfectants (EN16777) investigated.
All tested oral rinses except one reduced infectious viral titres to the lower limit of quantification. The two WHO-recommended hand-rub formulations as well as 30% ethanol and 2-propanol completely abolished the detection of infectious virus. Infectious RSV was recovered after several days on stainless steel discs. However, RSV was efficiently inactivated by all tested surface disinfectants based on alcohol, aldehyde, or hydrogen peroxide.
Oral rinses, all tested hand-rub formulations as well as surface inactivation reagents were sufficient for RSV inactivation in vitro.
呼吸道合胞病毒（RSV）是导致成人和儿童呼吸道感染的主要原因之一。病毒通过飞沫以及直接和间接接触（例如，受污染的表面或医务人员的手）在人与人之间传播。因此，适用的卫生措施和有关病毒失活的知识至关重要。
阐明 RSV 的消毒情况。
本研究通过定量悬浮试验（EN14476）评估了专为儿童设计的漱口液、世界卫生组织（WHO）推荐的手部揉搓制剂、乙醇和 2-丙醇对 RSV 的病毒杀灭效果。评估了 RSV 在不锈钢盘上的稳定性，并研究了不同表面消毒剂（EN16777）对其的灭活作用。
除一种外，所有测试的漱口液均将传染性病毒滴度降低到定量下限。两种 WHO 推荐的手部揉搓制剂以及 30%乙醇和 2-丙醇完全消除了可检测的感染性病毒。在不锈钢盘上几天后可回收感染性 RSV。然而，所有测试的基于酒精、醛或过氧化氢的表面消毒剂均可有效灭活 RSV。
漱口液、所有测试的手部揉搓制剂以及表面灭活试剂均可在体外有效灭活 RSV。
