戊型肝炎病毒在无生命物体表面的存活与灭活
Survival and inactivation of hepatitis E virus on inanimate surfaces.
作者信息
Wißmann J E, Brüggemann Y, Todt D, Steinmann J, Steinmann E
机构信息
Department for Molecular & Medical Virology, Ruhr University Bochum, Bochum, Germany.
Department for Molecular & Medical Virology, Ruhr University Bochum, Bochum, Germany; European Virus Bioinformatics Center (EVBC), Jena, Germany.
出版信息
J Hosp Infect. 2023 Apr;134:57-62. doi: 10.1016/j.jhin.2023.01.013. Epub 2023 Feb 4.
BACKGROUND
Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis, and mainly transmitted via faecal-oral contamination or consumption of contaminated food products. However, limited data on the surface stability and HEV sensitivity to chemical disinfectants are available.
AIM
To establish an HEV-based carrier assay to evaluate its surface stability and the virucidal activity of nine surface disinfectants.
METHODS
A recently developed robust HEV-3 cell culture system for an HEV-based carrier assay.
FINDINGS
Alcohol-based disinfectants were insufficient to eliminate HEV infectivity, whereas disinfectants based on aldehyde, peracetic acid, oxygen, and/or quaternary ammonium inactivated HEV.
CONCLUSION
These findings have strong implications for the recommendation of evidence-based hygiene guidelines to reduce HEV transmission.
背景
戊型肝炎病毒（HEV）是急性病毒性肝炎最常见的病因，主要通过粪口污染或食用受污染的食品传播。然而，关于其表面稳定性和对化学消毒剂敏感性的资料有限。
目的
建立基于戊型肝炎病毒的载体检测方法，以评估其表面稳定性和9种表面消毒剂的杀病毒活性。
方法
最近开发了一种用于基于戊型肝炎病毒载体检测的强大的HEV-3细胞培养系统。
研究结果
酒精类消毒剂不足以消除戊型肝炎病毒的传染性，而基于醛、过氧乙酸、氧和/或季铵盐的消毒剂可使戊型肝炎病毒失活。
结论
这些发现对推荐基于证据的卫生指南以减少戊型肝炎病毒传播具有重要意义。
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