Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & the Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, China.
Department of General Surgery, Rui Jin Hospital, Research Institute of Pancreatic Diseases, School of Medicine, Shanghai JiaoTong University, Shanghai 200025, China.
Biochim Biophys Acta Rev Cancer. 2023 Sep;1878(5):188965. doi: 10.1016/j.bbcan.2023.188965. Epub 2023 Aug 23.
Mitotic catastrophe is distinct from other cell death modes due to unique nuclear alterations characterized as multi and/or micronucleation. Mitotic catastrophe is a common and virtually unavoidable consequence during cancer therapy. However, a comprehensive understanding of mitotic catastrophe remains lacking. Herein, we summarize the anticancer drugs that induce mitotic catastrophe, including microtubule-targeting agents, spindle assembly checkpoint kinase inhibitors, DNA damage agents and DNA damage response inhibitors. Based on the relationships between mitotic catastrophe and other cell death modes, we thoroughly evaluated the roles played by mitotic catastrophe in cancer treatment as well as its advantages and disadvantages. Some strategies for overcoming its shortcomings while fully utilizing its advantages are summarized and proposed in this review. We also review how mitotic catastrophe regulates cancer immunotherapy. These summarized findings suggest that the induction of mitotic catastrophe can serve as a promising new therapeutic approach for overcoming apoptosis resistance and strengthening cancer immunotherapy.
有丝分裂灾难与其他细胞死亡模式不同，其特征是多核和/或微核等独特的核改变。有丝分裂灾难是癌症治疗过程中常见且几乎不可避免的后果。然而，人们对有丝分裂灾难的全面认识仍然不足。本文总结了诱导有丝分裂灾难的抗癌药物，包括微管靶向药物、纺锤体组装检查点激酶抑制剂、DNA 损伤剂和 DNA 损伤反应抑制剂。基于有丝分裂灾难与其他细胞死亡模式之间的关系，我们深入评估了有丝分裂灾难在癌症治疗中的作用及其优缺点。本文综述中总结并提出了克服其缺点而充分利用其优点的一些策略。我们还回顾了有丝分裂灾难如何调节癌症免疫治疗。这些总结的发现表明，诱导有丝分裂灾难可以作为一种有前途的新治疗方法，用于克服细胞凋亡抵抗和加强癌症免疫治疗。
