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Targeting receptor for activated C kinase 1 with a small molecule induces mitotic catastrophe and suppresses lipid metabolic reprogramming in hepatocellular carcinoma.

作者信息

Wang Longyan, Tan Peng, Wang Fei, Huang Huiming, Wei Xuejiao, Wang Zhuguo, Qiu Xinyu, Gao Yufeng, Zhang Ruoxin, Tu Pengfei, Li Jun, Hu Zhongdong

机构信息

Department of Pharmacology of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

Modern Research Centre for Traditional Chinese Medicine, Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

出版信息

Clin Transl Med. 2025 Aug;15(8):e70460. doi: 10.1002/ctm2.70460.

DOI:10.1002/ctm2.70460
PMID:40836602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12367861/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2588/12367861/15e0c7a0c841/CTM2-15-e70460-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2588/12367861/4d5a587650e7/CTM2-15-e70460-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2588/12367861/8280280b9a34/CTM2-15-e70460-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2588/12367861/a34d075d1fd6/CTM2-15-e70460-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2588/12367861/15e0c7a0c841/CTM2-15-e70460-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2588/12367861/4d5a587650e7/CTM2-15-e70460-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2588/12367861/8280280b9a34/CTM2-15-e70460-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2588/12367861/a34d075d1fd6/CTM2-15-e70460-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2588/12367861/15e0c7a0c841/CTM2-15-e70460-g002.jpg

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本文引用的文献

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Innovation (Camb). 2024 Apr 9;5(3):100625. doi: 10.1016/j.xinn.2024.100625. eCollection 2024 May 6.
2
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance.细胞周期停滞诱导脂滴形成并赋予铁死亡抗性。
Nat Commun. 2024 Jan 2;15(1):79. doi: 10.1038/s41467-023-44412-7.
3
Perspectives and mechanisms for targeting mitotic catastrophe in cancer treatment.
靶向癌症治疗中有丝分裂灾难的观点和机制。
Biochim Biophys Acta Rev Cancer. 2023 Sep;1878(5):188965. doi: 10.1016/j.bbcan.2023.188965. Epub 2023 Aug 23.
4
DHMMF, a natural flavonoid from Resina Draconis, inhibits hepatocellular carcinoma progression via inducing apoptosis and G2/M phase arrest mediated by DNA damage-driven upregulation of p21.DHMMF，一种来自血竭的天然类黄酮，通过诱导细胞凋亡和 G2/M 期阻滞，抑制肝癌的进展，其机制与 DNA 损伤驱动的 p21 上调有关。
Biochem Pharmacol. 2023 May;211:115518. doi: 10.1016/j.bcp.2023.115518. Epub 2023 Mar 24.
5
Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.肝癌中 Trip13 的耗竭诱导脂质生成反应，有助于 Plin2 依赖性有丝分裂细胞死亡。
Adv Sci (Weinh). 2022 Oct;9(29):e2104291. doi: 10.1002/advs.202104291. Epub 2022 Aug 28.
6
Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance.肝脏中RACK1基因的缺失会独立于胰岛素抵抗而扰乱脂质和葡萄糖稳态。
J Endocrinol. 2022 Aug 12;254(3):137-151. doi: 10.1530/JOE-22-0076. Print 2022 Sep 1.
7
Dragon's Blood from Worldwide: Species, Traditional Uses, Phytochemistry and Pharmacology.龙血树资源全球分布：种类、传统用途、植物化学和药理学研究。
Am J Chin Med. 2021;49(6):1315-1367. doi: 10.1142/S0192415X21500634. Epub 2021 Jul 10.
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