Tsikopoulos Alexios, Tsikopoulos Konstantinos, Meroni Gabriele, Drago Lorenzo, Triaridis Stefanos, Papaioannidou Paraskevi
1st Department of Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
1st Department of Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Voice. 2023 Aug 23. doi: 10.1016/j.jvoice.2023.07.015.
Lifetime elongation of the silicone voice rubber prostheses by inhibition of biofilm formation is a primary objective in voice restoration of laryngectomized patients. This systematic review sought to explore the existing strategies in this direction.
We conducted a systematic search of both in vitro and in vivo literature published in PubMed, Scopus, and Cochrane Central Register of Controlled Trials, until December 31, 2022, for published and unpublished trials assessing the strategies for inhibiting biofilm formation on silicone rubber voice prostheses, and appraised quality assessment with the modified Consolidated Standards of Reporting Trials tool. We analyzed the infection prevention capacity of the included antibacterial and antifungal agents.
The qualitative synthesis showed that both surface modification methods and prophylactic treatment of silicone rubber voice prostheses present adequate antibiofilm activity. Of note, the majority of the suggested prosthetic surfaces were not chronically exposed to both human fluids and biofilm-forming microorganisms.
Various experimental methods provide promising antibiofilm activity and, thus, possible lifespan elongation of silicone rubber voice prostheses.
通过抑制生物膜形成来延长硅橡胶语音假体的使用寿命是喉切除患者语音恢复的主要目标。本系统评价旨在探索这方面的现有策略。
我们对截至2022年12月31日发表在PubMed、Scopus和Cochrane对照试验中央注册库中的体外和体内文献进行了系统检索，以查找评估抑制硅橡胶语音假体生物膜形成策略的已发表和未发表试验，并使用改良的报告试验统一标准工具进行质量评估。我们分析了所纳入的抗菌和抗真菌剂的感染预防能力。
定性综合分析表明，硅橡胶语音假体的表面改性方法和预防性治疗均具有足够的抗生物膜活性。值得注意的是，大多数建议的假体表面并未长期暴露于人体体液和生物膜形成微生物中。
各种实验方法都具有良好的抗生物膜活性，因此有可能延长硅橡胶语音假体的使用寿命。
