Department of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University, Luzhou, China.
Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, China.
Front Endocrinol (Lausanne). 2022 Nov 18;13:1037969. doi: 10.3389/fendo.2022.1037969. eCollection 2022.
This study aimed to evaluate the relationship between thyroid-related hormones and vascular complications in type 2 diabetes mellitus (T2DM) patients with euthyroidism.
We enrolled 849 patients with T2DM after screening out the ineligible. Multivariate logistic regression was used to analyze the relationship between fT3, fT4, the fT3/fT4 ratio, thyroid-stimulating hormone, and diabetic vascular complications. Spearman correlation analysis was used to determine the correlation between thyroid-related hormones and vascular complications.
In this cross-sectional study of T2DM, 538 patients with carotid atherosclerosis (CA) and 299 patients with diabetic peripheral neuropathy (DPN). The prevalence of DPN was negatively correlated with fT3 and the fT3/fT4 ratio but positively correlated with fT4 (all P<0.01). At the same time, the odds ratio for DPN decreased with increasing fT3 (T1: reference; T2: OR: 0.689, 95%CI: 0.477, 0.993; T3: OR: 0.426, 95% CI: 0.286, 0.633, all P<0.05) and fT3/fT4 ratio (T1: reference; T2: OR: 0.528, 95% CI: 0.365, 0.763; T3: OR: 0.413, 95% CI: 0.278, 0.613, all P<0.001). In terms of sensitivity and specificity, fT4 was found to be 39.5% and 71.4% accurate, respectively, with a 95% CI of 0.531-0.611.
We found a negative correlation between fT3 and fT3/fT4 ratio and the number of individuals with DPN, and a positive correlation between fT4 and the prevalence of DPN.
本研究旨在评估甲状腺相关激素与甲状腺功能正常的 2 型糖尿病（T2DM）患者血管并发症之间的关系。
我们筛选出不合格的患者后，共纳入 849 例 T2DM 患者。采用多变量 logistic 回归分析 fT3、fT4、fT3/fT4 比值、促甲状腺激素与糖尿病血管并发症之间的关系。采用 Spearman 相关分析来确定甲状腺相关激素与血管并发症之间的相关性。
在这项 T2DM 的横断面研究中，538 例患者患有颈动脉粥样硬化（CA），299 例患者患有糖尿病周围神经病变（DPN）。DPN 的患病率与 fT3 和 fT3/fT4 比值呈负相关，但与 fT4 呈正相关（均 P<0.01）。同时，随着 fT3 增加，DPN 的比值比（OR）降低（T1：参考；T2：OR：0.689，95%CI：0.477，0.993；T3：OR：0.426，95%CI：0.286，0.633，均 P<0.05）和 fT3/fT4 比值（T1：参考；T2：OR：0.528，95%CI：0.365，0.763；T3：OR：0.413，95%CI：0.278，0.613，均 P<0.001）。fT4 的灵敏度和特异性分别为 39.5%和 71.4%，95%CI 为 0.531-0.611。
我们发现 fT3 和 fT3/fT4 比值与 DPN 患者数量呈负相关，fT4 与 DPN 的患病率呈正相关。
