Rega Institute for Medical Research, Herestraat 49, B-3000 Leuven, Belgium.
Viruses. 2022 Nov 10;14(11):2484. doi: 10.3390/v14112484.
That cidofovir, an acyclic nucleoside phosphonate (ANP), was inhibitory to the replication of poxviruses was first demonstrated by De Clercq et al.. That its active metabolite, the diphosphate, was found to be inhibitory to the molluscum contagiosum () DNA polymerase was demonstrated by Watanabe and Tamaki. Twelve different independent observations have then indicated that cidofovir administered intravenously, topically or intralesionally is efficacious in the treatment of mostly in immunosuppressed patients.
西多福韦（cidofovir）是一种无环核苷膦酸（acyclic nucleoside phosphonate，ANP），De Clercq 等人首次证明其对痘病毒的复制具有抑制作用。Watanabe 和 Tamaki 则证明其活性代谢物二磷酸酯（diphosphate）对传染性软疣（molluscum contagiosum）DNA 聚合酶具有抑制作用。随后，有 12 项独立的观察结果表明，静脉内、局部或皮损内给予西多福韦对治疗有效，主要用于治疗免疫功能低下的患者。
