Chen Wenbo, Chen Xin, Zhao Zhenyu, Li Menglu, Dong Shuang, Hu Sheng, Li Xiaoyu, Feng Mingqian, Chen Ke, Zhong Shan, He Chunjiang
School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China.
Biology (Basel). 2023 Aug 14;12(8):1129. doi: 10.3390/biology12081129.
Metabolic dysregulation has been reported involving in the clinical outcomes of multiple cancers. However, systematical identification of the impact of metabolic pathways on cancer prognosis is still lacking. Here, we performed a pan-cancer analysis of popular metabolic checkpoint genes and pathways with cancer prognosis by integrating information of clinical survival with gene expression and pathway activity in multiple cancer patients. By discarding the effects of age and sex, we revealed extensive and significant associations between the survival of cancer patients and the expression of metabolic checkpoint genes, as well as the activities of three primary metabolic pathways: amino acid metabolism, carbohydrate metabolism, lipid metabolism, and eight nonprimary metabolic pathways. Among multiple cancers, we found the survival of kidney renal clear cell carcinoma and low-grade glioma exhibit high metabolic dependence. Our work systematically assesses the impact of metabolic checkpoint genes and pathways on cancer prognosis, providing clues for further study of cancer diagnosis and therapy.
代谢失调已被报道与多种癌症的临床结局有关。然而，目前仍缺乏对代谢途径对癌症预后影响的系统性鉴定。在此，我们通过整合多例癌症患者的临床生存信息与基因表达及途径活性，对常见的代谢检查点基因和途径与癌症预后进行了泛癌分析。通过排除年龄和性别的影响，我们揭示了癌症患者的生存与代谢检查点基因的表达以及三种主要代谢途径（氨基酸代谢、碳水化合物代谢、脂质代谢）和八种非主要代谢途径的活性之间存在广泛且显著的关联。在多种癌症中，我们发现肾透明细胞癌和低级别胶质瘤的生存表现出高度的代谢依赖性。我们的工作系统地评估了代谢检查点基因和途径对癌症预后的影响，为进一步研究癌症诊断和治疗提供了线索。
