Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, 28500 Madrid, Spain.
Institute of Molecular Pathology Biomarkers, Universidad de Extremadura, 10071 Cáceres, Spain.
Biomolecules. 2023 Aug 18;13(8):1263. doi: 10.3390/biom13081263.
The possible usefulness of alpha-synuclein (aSyn) determinations in peripheral tissues (blood cells, salivary gland biopsies, olfactory mucosa, digestive tract, skin) and in biological fluids, except for cerebrospinal fluid (serum, plasma, saliva, feces, urine), as a marker of several diseases, has been the subject of numerous publications. This narrative review summarizes data from studies trying to determine the role of total, oligomeric, and phosphorylated aSyn determinations as a marker of various diseases, especially PD and other alpha-synucleinopathies. In summary, the results of studies addressing the determinations of aSyn in its different forms in peripheral tissues (especially in platelets, skin, and digestive tract, but also salivary glands and olfactory mucosa), in combination with other potential biomarkers, could be a useful tool to discriminate PD from controls and from other causes of parkinsonisms, including synucleinopathies.
α-突触核蛋白（aSyn）在周围组织（血细胞、唾液腺活检、嗅黏膜、消化道、皮肤）和生物体液中的测定（除脑脊液外，如血清、血浆、唾液、粪便、尿液）作为几种疾病的标志物的可能有用性，一直是许多出版物的主题。本综述总结了试图确定总、寡聚和磷酸化 aSyn 测定作为各种疾病标志物（尤其是 PD 和其他α-突触核蛋白病）的研究数据。总之，研究 aSyn 不同形式在周围组织（特别是血小板、皮肤和消化道，以及唾液腺和嗅黏膜）中的测定结果，结合其他潜在的生物标志物，可能是区分 PD 与对照组以及与其他帕金森病病因（包括突触核蛋白病）的有用工具。
