Bhattacharyya S, Chakrabarty N G, Chattopadhyay U
Neoplasma. 1986;33(4):519-26.
The phagocytic activity of the tumor associate macrophages isolated at different days of the growth of a murine transplantable ascites tumor was assessed by measuring the engulfment of Na2 51CrO4 labeled antibody coated sheep erythrocytes. Binding of the targets by the macrophages was also assessed. It was observed that, excepting the day 3, till day 7 of tumor growth the phagocytic activity of the tumor associated macrophages was very high as compared to that of resident macrophages of normal mice. Augmented target binding by the macrophages was recorded till day 7. Levamisole was observed to augment phagocytosis and target binding by the macrophages but a differential requirement as regard to the dose of Levamisole was noted for modulation of phagocytosis and target binding by the tumor associated macrophages at early and advanced stages of the tumor growth.
通过测量对用Na2 51CrO4标记的抗体包被的绵羊红细胞的吞噬作用，评估在小鼠可移植腹水瘤生长的不同天数分离出的肿瘤相关巨噬细胞的吞噬活性。还评估了巨噬细胞对靶标的结合。观察到，除第3天外，直到肿瘤生长第7天，肿瘤相关巨噬细胞的吞噬活性与正常小鼠的驻留巨噬细胞相比都非常高。直到第7天巨噬细胞对靶标的结合都有所增强。观察到左旋咪唑可增强巨噬细胞的吞噬作用和对靶标的结合，但在肿瘤生长的早期和晚期，调节肿瘤相关巨噬细胞的吞噬作用和对靶标的结合时，对左旋咪唑剂量的要求有所不同。
