Weeks Caroline, Jackson Sarah, Demirel Nadir, Olson Janelle, Dean Vicki, Pyrz Caitlin, Creo Ana L
Mayo Clinic Pediatric Endocrinology Cystic Fibrosis Center, Mayo Clinic, Rochester, MN 55905, USA.
Division of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Children (Basel). 2023 Jul 31;10(8):1317. doi: 10.3390/children10081317.
Oral glucose tolerance testing is recommended for all children with CF older than 9 years, yet compliance remains poor across centers.
We performed a small pilot study assessing the glycemic curves and participant satisfaction in seven children and adolescents.
We chose a dextrose-based candy (Nerds) free of any fat, fiber, gelatin, or corn syrup and performed the candy OGTT 1-4 days following the standard oral dextrose solution OGTT. Glucose values at 120 min were similar between the candy and oral dextrose solution ( = 0.8986).
Our small pilot suggests that a carefully selected candy alternative may result in similar glycemic OGTT when compared to the standard oral dextrose solution. However, some participants preferred the oral dextrose solution to candy due to having to consume a large volume in a short period of time. This may have significant implications as centers consider candy alternatives to increase OGTT adherence rates.
建议对所有9岁以上的囊性纤维化（CF）儿童进行口服葡萄糖耐量试验，但各中心的依从性仍然很差。
我们开展了一项小型试点研究，评估7名儿童和青少年的血糖曲线及参与者满意度。
我们选择了一种不含任何脂肪、纤维、明胶或玉米糖浆的葡萄糖基糖果（小熊软糖），并在标准口服葡萄糖溶液口服葡萄糖耐量试验后的1-4天进行了糖果口服葡萄糖耐量试验。糖果组和口服葡萄糖溶液组在120分钟时的血糖值相似（ = 0.8986）。
我们的小型试点研究表明，与标准口服葡萄糖溶液相比，精心挑选的糖果替代品可能会产生相似的口服葡萄糖耐量试验血糖结果。然而，一些参与者由于需要在短时间内摄入大量糖果，因此更喜欢口服葡萄糖溶液而非糖果。随着各中心考虑使用糖果替代品来提高口服葡萄糖耐量试验的依从率，这可能具有重大意义。
