Chen Wenwen, Zhang Zhenhai, Xu Liping, Chen Chao
Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital, Fujian Medical University, Zhangzhou 363000, China.
Children's Hospital, Fudan University, Shanghai 201102, China.
Children (Basel). 2023 Aug 11;10(8):1373. doi: 10.3390/children10081373.
It is urgent to make a rapid screening of infants at the highest risk for bronchopulmonary dysplasia (BPD) via some succinct postnatal biomarkers, such as () infection and chest radiograph images.
A retrospective study was performed. Moderate to severe BPD or death was set as the main outcome. The association between putative variables and the main outcome were assessed by bivariate analyses and logistic regression.
A total of 134 infants were enrolled. Bivariate analyses showed the gestational age, birth weight, appearances of diffuse opacities or grid shadows/interstitial opacities or mass opacities or cystic lucencies on chest radiographic images, a ductal diameter ≥1.5 mm and whether infection was associated with BPD. After adjustment by logistic regression, the risk of BPD with gestational age, sex and specific chest-radiographic manifestations remained significant.
Chest radiograph images (appearance of diffuse opacities or grid shadows/interstitial opacities or mass opacities or cystic lucencies) could provide a quick prediction of developing BPD in clinical practice, in addition to gestational age and sex. infection was not an independent risk factor for BPD.
通过一些简洁的产后生物标志物，如（）感染和胸部X光片图像，对支气管肺发育不良（BPD）风险最高的婴儿进行快速筛查迫在眉睫。
进行了一项回顾性研究。将中度至重度BPD或死亡设定为主要结局。通过双变量分析和逻辑回归评估假定变量与主要结局之间的关联。
共纳入134例婴儿。双变量分析显示，胎龄、出生体重、胸部X光片图像上弥漫性模糊影或网格状阴影/间质模糊影或团块状阴影或囊状透亮区的表现、导管直径≥1.5毫米以及是否（）感染与BPD相关。经逻辑回归调整后，胎龄、性别和特定胸部X光表现与BPD的风险仍具有显著相关性。
除胎龄和性别外，胸部X光片图像（弥漫性模糊影或网格状阴影/间质模糊影或团块状阴影或囊状透亮区的表现）在临床实践中可为BPD的发生提供快速预测。（）感染不是BPD的独立危险因素。
