Department of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao 266000, China.
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Genes (Basel). 2023 Jul 25;14(8):1516. doi: 10.3390/genes14081516.
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) are biologically active substances secreted by MSCs into the extracellular matrix that play an immunomodulatory role in skin damage repair. To investigate the mechanism of MSC-EVs in reducing inflammation, promoting angiogenesis, promoting the proliferation and migration of epithelial cells and fibroblasts, and extracellular matrix remodeling during wound healing, we focused on the effects of EVs on multiple cell types at various stages of skin injury. A literature review was conducted to explore related research on the influence of MSC-EVs on the types of cells involved in wound healing. MSC-EVs show a strong regulatory ability on immune cells involved in the regulation of inflammation, including macrophages, neutrophils, and T cells, and other cells involved in tissue proliferation and remodeling, such as fibroblasts, keratinocytes, and endothelial cells, during wound healing in in vitro and in vivo experiments, which substantially promoted the understanding of wound healing in the field of trauma medicine. MSC-EVs have potential applications in combating poor skin wound healing. Elucidating the mechanism of action of EVs in the wound-healing process would greatly advance the understanding of therapeutic wound healing.
间充质干细胞衍生的细胞外囊泡（MSC-EVs）是间充质干细胞分泌到细胞外基质中的具有生物活性的物质，在皮肤损伤修复中发挥免疫调节作用。为了研究 MSC-EVs 在减轻炎症、促进血管生成、促进上皮细胞和成纤维细胞增殖和迁移以及细胞外基质重塑方面的作用机制，我们重点研究了 EVs 对皮肤损伤不同阶段的多种细胞类型的影响。进行了文献回顾，以探讨有关 MSC-EVs 对参与伤口愈合的细胞类型影响的相关研究。MSC-EVs 在体外和体内实验中对参与炎症调节的免疫细胞（包括巨噬细胞、中性粒细胞和 T 细胞）以及其他参与组织增殖和重塑的细胞（如成纤维细胞、角质形成细胞和内皮细胞）具有很强的调节能力，这极大地促进了创伤医学领域对伤口愈合的理解。MSC-EVs 在对抗皮肤伤口愈合不良方面具有潜在应用。阐明 EVs 在伤口愈合过程中的作用机制将极大地促进对治疗性伤口愈合的理解。
