Department of Clinical Immunology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Servicio de Alergia, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain.
Int J Mol Sci. 2023 Aug 12;24(16):12725. doi: 10.3390/ijms241612725.
Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine that has emerged as a critical player in the development and progression of allergy and asthma. It is primarily produced by epithelial cells and functions as a potent immune system activator. TSLP acts through interaction with its receptor complex, composed of the TSLP receptor (TSLPR) and interleukin-7 receptor alpha chain (IL-7Rα), activating downstream complex signalling pathways. The TSLP major isoform, known as long-form TSLP (lfTSLP), is upregulated in the airway epithelium of patients with allergic diseases. More research is warranted to explore the precise mechanisms by which short-form TSLP (sfTSLP) regulates immune responses. Understanding the dynamic interplay between TSLP and the dysfunctional epithelium provides insights into the mechanisms underlying allergy and asthma pathogenesis. Targeting TSLP represents an important therapeutic strategy, as it may upstream disrupt the inflammatory cascade and alleviate symptoms associated with allergic inflammation.
胸腺基质淋巴细胞生成素 (TSLP) 是一种多效细胞因子，已成为过敏和哮喘发展和进展的关键因素。它主要由上皮细胞产生，作为一种强大的免疫系统激活剂。TSLP 通过与其受体复合物相互作用发挥作用，该复合物由 TSLP 受体 (TSLPR) 和白细胞介素-7 受体 α 链 (IL-7Rα) 组成，激活下游复杂的信号通路。TSLP 的主要同工型，称为长型 TSLP (lfTSLP)，在过敏疾病患者的气道上皮中上调。需要更多的研究来探索短型 TSLP (sfTSLP) 调节免疫反应的确切机制。了解 TSLP 与功能失调的上皮细胞之间的动态相互作用为过敏和哮喘发病机制的机制提供了深入的了解。靶向 TSLP 是一种重要的治疗策略，因为它可能在上游破坏炎症级联反应并减轻与过敏炎症相关的症状。
