Department of Dermatology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Mediators Inflamm. 2023 Apr 15;2023:7697699. doi: 10.1155/2023/7697699. eCollection 2023.
Atopic dermatitis (AD) is a kind of chronic skin disease with inflammatory infiltration, characterized by skin barrier dysfunction, immune response dysregulation, and skin dysbiosis. Thymic stromal lymphopoietin (TSLP) acts as a regulator of immune response, positively associated with AD deterioration. Mainly secreted by keratinocytes, TSLP interacts with multiple immune cells (including dendritic cells, T cells, and mast cells), following induction of Th2-oriented immune response during the pathogenesis of AD. This article primarily focuses on the TSLP biological function, the relationship between TSLP and different cell populations, and the AD treatments targeting TSLP.
特应性皮炎（AD）是一种慢性炎症性皮肤病，其特征为皮肤屏障功能障碍、免疫反应失调和皮肤微生态失衡。胸腺基质淋巴细胞生成素（TSLP）作为免疫反应的调节剂，与 AD 的恶化呈正相关。TSLP 主要由角质形成细胞分泌，与多种免疫细胞（包括树突状细胞、T 细胞和肥大细胞）相互作用，在 AD 的发病机制中诱导 Th2 定向免疫反应。本文主要关注 TSLP 的生物学功能、TSLP 与不同细胞群的关系，以及针对 TSLP 的 AD 治疗方法。
