School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Centre for Microbial Genomics and Proteomics, The Chinese University of Hong Kong, Hong Kong.
Int J Mol Sci. 2023 Aug 16;24(16):12856. doi: 10.3390/ijms241612856.
Imbalance of the immune system caused by alterations of the gut microbiome is considered to be a critical factor in the pathogenesis of infant eczema, but the exact role of the gut microbiome in adult atopic dermatitis (AD) patients remains to be clarified. To investigate the differences of the gut microbiome between adult AD patients and healthy individuals, stool samples of 234 adults, containing 104 AD patients and 130 healthy subjects, were collected for 16S rRNA gene amplicon. Altered structure and metabolic dysfunctions of the gut microbiome were identified in adult AD patients. Our results illustrated that the adult AD patients were more likely to have allergies, particularly non-food allergies. In addition, the gut microbiome composition of the AD and normal groups were considerably different. Moreover, and was enriched in the normal group, whereas , , , , , , , and dominated in the AD group. Additionally, purine nucleotide degradation pathways were significantly enriched in the AD group, and the enrichment of proteinogenic amino acid biosynthesis pathways was found in the normal group. This study provides insights into new therapeutic strategies targeting the gut microbiome for AD and evidence for the involvement of the gut-skin axis in AD patients.
肠道微生物组的改变导致免疫系统失衡被认为是婴儿湿疹发病机制中的一个关键因素，但肠道微生物组在成人特应性皮炎（AD）患者中的确切作用仍有待阐明。为了研究成人 AD 患者与健康个体之间肠道微生物组的差异，我们收集了 234 名成年人的粪便样本，其中包括 104 名 AD 患者和 130 名健康受试者，用于 16S rRNA 基因扩增。在成人 AD 患者中发现了肠道微生物组结构和代谢功能的改变。我们的研究结果表明，成人 AD 患者更容易发生过敏，尤其是非食物过敏。此外，AD 组和正常组的肠道微生物组组成有很大差异。此外，在正常组中富集了 ，而在 AD 组中富集了 、 、 、 、 、 、 。此外，嘌呤核苷酸降解途径在 AD 组中显著富集，而在正常组中发现了蛋白质氨基酸生物合成途径的富集。本研究为针对 AD 的肠道微生物组的新治疗策略提供了新的见解，并为肠道-皮肤轴在 AD 患者中的参与提供了证据。
