靶向 SARS-CoV-2 非结构蛋白。
Targeting SARS-CoV-2 Non-Structural Proteins.
机构信息
Division of Infectious Disease, Department of Medicine, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.
Laboratorio de Investigación Fitoquímica, Departamento de Ciencias Químico Biológicas, Universidad de las Américas Puebla, Ex Hacienda Sta. Catarina Mártir S/N, San Andrés Cholula 72810, Mexico.
出版信息
Int J Mol Sci. 2023 Aug 20;24(16):13002. doi: 10.3390/ijms241613002.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped respiratory β coronavirus that causes coronavirus disease (COVID-19), leading to a deadly pandemic that has claimed millions of lives worldwide. Like other coronaviruses, the SARS-CoV-2 genome also codes for non-structural proteins (NSPs). These NSPs are found within open reading frame 1a (ORF1a) and open reading frame 1ab (ORF1ab) of the SARS-CoV-2 genome and encode NSP1 to NSP11 and NSP12 to NSP16, respectively. This study aimed to collect the available literature regarding NSP inhibitors. In addition, we searched the natural product database looking for similar structures. The results showed that similar structures could be tested as potential inhibitors of the NSPs.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是一种包膜呼吸道β冠状病毒，可引起冠状病毒病（COVID-19），导致致命的大流行，在全球范围内夺走了数百万人的生命。与其他冠状病毒一样，SARS-CoV-2 基因组还编码非结构蛋白（NSPs）。这些 NSP 存在于 SARS-CoV-2 基因组的开放阅读框 1a（ORF1a）和开放阅读框 1ab（ORF1ab）中，分别编码 NSP1 至 NSP11 和 NSP12 至 NSP16。本研究旨在收集有关 NSP 抑制剂的现有文献。此外，我们还搜索了天然产物数据库，寻找类似的结构。结果表明，类似的结构可以作为 NSP 的潜在抑制剂进行测试。
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