Hening W A, Walters A, Kavey N, Gidro-Frank S, Côté L, Fahn S
Neurology. 1986 Oct;36(10):1363-6. doi: 10.1212/wnl.36.10.1363.
In five unrelated patients with the restless legs syndrome, opioid drugs relieved restlessness, dysesthesias, dyskinesias while awake, periodic movements of sleep, and sleep disturbances. When naloxone was given parenterally to two treated patients, the signs and symptoms of the restless legs syndrome reappeared. Naloxone placebo had no effect. Opioid medications may offer a useful therapy for the restless legs syndrome. The endogenous opiate system may be involved in the pathogenesis of the syndrome.
在5例不相关的不安腿综合征患者中，阿片类药物缓解了清醒时的烦躁不安、感觉异常、运动障碍、睡眠周期性运动及睡眠障碍。当对2例接受治疗的患者胃肠外给予纳洛酮时，不安腿综合征的体征和症状再次出现。纳洛酮安慰剂无作用。阿片类药物可能为不安腿综合征提供一种有效的治疗方法。内源性阿片系统可能参与了该综合征的发病机制。
