Montplaisir J, Godbout R, Boghen D, DeChamplain J, Young S N, Lapierre G
Neurology. 1985 Jan;35(1):130-4. doi: 10.1212/wnl.35.1.130.
Restless legs syndrome was present in nine members of a family over a span of five generations. In three subjects, the diagnosis was confirmed by all-night sleep recordings and concomitant EMG. Two of these three subjects also had periodic movements in sleep. The frequency of leg movements decreased from wakefulness to stages 1 and 2 non-REM sleep. There was an increase of free dopamine and homovanillic acid in CSF of the propositus. Clonazepam effectively controlled restless legs in the propositus and his mother.
不安腿综合征在一个家族的五代人中的九名成员中出现。在三名受试者中，通过整夜睡眠记录和同步肌电图证实了诊断。这三名受试者中的两名在睡眠中也有周期性运动。腿部运动的频率从清醒状态到非快速眼动睡眠1期和2期有所下降。先证者的脑脊液中游离多巴胺和高香草酸增加。氯硝西泮有效控制了先证者及其母亲的不安腿症状。
