Anastasilakis Athanasios D, Polyzos Stergios A, Vorkas Panagiotis A, Gkiomisi Athina, Yavropoulou Maria P, Rauner Martina, Nikolakopoulos Panagiotis, Papachatzopoulos Stergios, Makras Polyzois, Gerou Spyridon, Hofbauer Lorenz C, Palermo Andrea, Tsourdi Elena
Department of Endocrinology, 424 Military General Hospital, 56429 Thessaloniki, Greece.
First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
J Clin Med. 2023 Aug 21;12(16):5430. doi: 10.3390/jcm12165430.
The lipid profile is affected following menstrual cessation (MC). We aimed to evaluate the effects of goserelin-induced MC and subsequent menstrual restoration (MR) on lipid metabolism. Premenopausal women with histologically verified endometriosis (n = 15) received goserelin monthly for 6 months (6mο), resulting in MC, and were followed-up for another 6 months after MR (12mο). Serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), lipoprotein a ([Lp(a)] and lipidomics were measured at baseline, 6mo and 12mo. Shotgun quantitative deep lipidomics were determined at the level of lipid class category, subclass, species, and fatty acyl chain lengths and degree of saturation. TC ( = 0.006), LDL-C ( = 0.028), HDL-C ( = 0.002), and apoA1 ( = 0.013) increased during goserelin-induced MC and remained practically unchanged during MR. TG, apoB, and Lp(a) did not change. From the deep lipidomics analysis, multivariate statistical analysis demonstrated profound alterations in lipid species with MC, whereas no statistically valid models could be fitted for the restoration period. In conclusion, GnRH-analog-induced MC alters lipid profiles at various levels, from standard blood lipid and lipoprotein profiles to several lipid species as detected by lipidomics analysis. Changes largely persist for at least 6 m after MR.
绝经后脂质谱会受到影响。我们旨在评估戈舍瑞林诱导的绝经及随后的月经恢复对脂质代谢的影响。组织学确诊为子宫内膜异位症的绝经前女性（n = 15）每月接受戈舍瑞林治疗6个月（6个月），导致绝经，并在月经恢复后再随访6个月（12个月）。在基线、6个月和12个月时测量血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）、脂蛋白a（[Lp(a)]）和脂质组学。在脂质类别、亚类、种类以及脂肪酰链长度和饱和度水平上进行鸟枪法定量深度脂质组学分析。在戈舍瑞林诱导的绝经期间，TC（P = 0.006）、LDL-C（P = 0.028）、HDL-C（P = 0.002）和载脂蛋白A1（P = 0.013）升高，在月经恢复期间基本保持不变。TG、载脂蛋白B和Lp(a)没有变化。从深度脂质组学分析来看，多变量统计分析表明绝经时脂质种类发生了深刻变化，而在恢复期间无法拟合出具有统计学意义的有效模型。总之，GnRH类似物诱导的绝经会在从标准血脂和脂蛋白谱到脂质组学分析检测到的几种脂质种类等多个水平上改变脂质谱。这些变化在月经恢复后至少6个月内基本持续存在。
