National Institute of Rheumatic Diseases, Nabrezie I. Krasku 4, 921 12 Piestany, Slovakia.
Department of Urology, Faculty of Medicine, Comenius University in Bratislava, Limbova 5, 833 05 Bratislava, Slovakia.
Medicina (Kaunas). 2023 Aug 3;59(8):1416. doi: 10.3390/medicina59081416.
Tissue engineering (TE) is a rapidly evolving biomedical discipline that can play an important role in treating neurogenic bladder dysfunction and compensating for current conventional options' shortcomings. This review aims to analyze the current status of preclinical and clinical trials and discuss what could be expected in the future based on the current state of the art. Although most preclinical studies provide promising results on the effectiveness of TE and stem cell therapies, the main limitations are mainly the very slow translation of preclinical trials to clinical trials, lack of quality research on neurogenic preconditions of neurogenic bladder dysfunction outside of the spinal cord injury and varying therapeutic methods of the existing research that lacks a standardized approach.
组织工程（TE）是一个快速发展的生物医学学科，可以在治疗神经源性膀胱功能障碍和弥补当前常规治疗方法的不足方面发挥重要作用。本综述旨在分析当前的临床前和临床试验现状，并根据现有技术水平讨论未来可能的发展方向。尽管大多数临床前研究提供了关于 TE 和干细胞治疗有效性的有希望的结果，但主要的局限性主要是临床前试验向临床试验的转化非常缓慢，缺乏对脊髓损伤以外的神经源性膀胱功能障碍的神经源性前提的高质量研究，以及现有的治疗方法缺乏标准化方法，治疗方法各不相同。
