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基于力响应的机器人辅助切割角膜的力学评估

A Mechanical Evaluation of a Robot-Assisted Cutting Cornea Based on Force Response.

作者信息

Zhang Qinran, Zhao Jingyu, Wang Sikai, Deng Shijing, Su Peng

机构信息

School of Electromechanical Engineering, Beijing Information Science and Technology University, Beijing 100192, China.

Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Capital Medical University, Beijing 100730, China.

出版信息

Micromachines (Basel). 2023 Aug 19;14(8):1634. doi: 10.3390/mi14081634.

DOI:10.3390/mi14081634
PMID:37630170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10457903/
Abstract

The aim of this paper is to propose laws of trephine operation based on a robot-assisted cutting cornea in order to obtain better microsurgical effects for keratoplasty. Using a trephine robot integrated with a microforce sensor and a handheld trephine manipulator, robotic and manual experiments were performed, with porcine corneas as the test subjects. The effect of trephine operational parameters on the results reflected by the biomechanical response is discussed, and the parameters include linear velocity, rotating angle, and angular velocity. Using probability density functions, the distributions of the manual operational parameters show some randomness, and there is a large fluctuation in the trephine force during the experiments. The biomechanical response shows regular trends in the robotic experiments even under different parameters, and compared to manual trephination, the robot may perform the operation of trephine cornea cutting more stably. Under different operational parameters, the cutting force shows different trends, and the optimal initial parameters that result in better trephine effects can be obtained based on the trends. Based on this derived law, the operational parameters can be set in robotic trephination, and surgeons can also be specially trained to achieve a better microsurgical result.

摘要

本文旨在基于机器人辅助切割角膜提出环钻手术的规律,以便在角膜移植术中获得更好的显微手术效果。使用集成了微力传感器的环钻机器人和手持式环钻操纵器,以猪角膜为测试对象进行了机器人和手动实验。讨论了环钻操作参数对生物力学响应所反映结果的影响,这些参数包括线速度、旋转角度和角速度。使用概率密度函数,手动操作参数的分布呈现出一定的随机性,并且在实验过程中环钻力存在较大波动。即使在不同参数下,生物力学响应在机器人实验中也呈现出规律的趋势,与手动环钻相比,机器人进行角膜环钻切割操作可能更稳定。在不同操作参数下,切割力呈现出不同的趋势,基于这些趋势可以获得导致更好环钻效果的最佳初始参数。基于此推导的规律,可以在机器人环钻中设置操作参数,外科医生也可以接受专门培训以获得更好的显微手术结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/7658adc3c77b/micromachines-14-01634-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/8cd83faefe79/micromachines-14-01634-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/1964b9155ab4/micromachines-14-01634-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/2bad1340e29a/micromachines-14-01634-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/50f19f8997a3/micromachines-14-01634-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/0edad05242ca/micromachines-14-01634-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/f2434021ad39/micromachines-14-01634-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/7658adc3c77b/micromachines-14-01634-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/8cd83faefe79/micromachines-14-01634-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/1964b9155ab4/micromachines-14-01634-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/2bad1340e29a/micromachines-14-01634-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/50f19f8997a3/micromachines-14-01634-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/0edad05242ca/micromachines-14-01634-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/f2434021ad39/micromachines-14-01634-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/950b/10457903/7658adc3c77b/micromachines-14-01634-g007.jpg

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本文引用的文献

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Femtosecond Laser-Assisted Ophthalmic Surgery: From Laser Fundamentals to Clinical Applications.飞秒激光辅助眼科手术:从激光基础到临床应用
Micromachines (Basel). 2022 Sep 30;13(10):1653. doi: 10.3390/mi13101653.
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Deep Anterior Lamellar Keratoplasty: Current Status and Future Directions.深层板层角膜移植术:现状与未来方向。
Cornea. 2022 May 1;41(5):539-544. doi: 10.1097/ICO.0000000000002840.
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Biomechanical Effects of Deep Anterior Lamellar Keratoplasty and Penetrating Keratoplasty for Keratoconus: A Finite Element Analysis.
深板层角膜切开术和穿透性角膜移植术治疗圆锥角膜的生物力学效应:有限元分析。
Transl Vis Sci Technol. 2021 Aug 2;10(9):15. doi: 10.1167/tvst.10.9.15.
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Mechanical Properties of Bioengineered Corneal Stroma.生物工程角膜基质的力学性能
Adv Healthc Mater. 2021 Oct;10(20):e2100972. doi: 10.1002/adhm.202100972. Epub 2021 Aug 8.
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Design and implementation of a hand-held robot-assisted minimally invasive surgical device with enhanced intuitive manipulability and stable grip force.一种具有增强直观操作性和稳定夹持力的手持式机器人辅助微创手术装置的设计与实现。
Int J Med Robot. 2021 Aug;17(4):e2286. doi: 10.1002/rcs.2286. Epub 2021 May 26.
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Animal model with structural similarity to human corneal collagen fibrillar arrangement.具有与人眼角膜胶原纤维排列结构相似的动物模型。
Anat Sci Int. 2021 Mar;96(2):286-293. doi: 10.1007/s12565-020-00590-8. Epub 2021 Jan 3.
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Variable Responses to Corneal Grafts: Insights from Immunology and Systems Biology.角膜移植的可变反应:来自免疫学和系统生物学的见解
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Intraocular Pressure Measurement Using Ocular Response Analyzer, Dynamic Contour Tonometer, and Scheimpflug Analyzer Corvis ST.使用眼反应分析仪、动态轮廓眼压计和角膜生物力学分析仪Corvis ST测量眼压
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Comparison of corneal biomechanical properties following penetrating keratoplasty and deep anterior lamellar keratoplasty for keratoconus.比较圆锥角膜行穿透性角膜移植术与深板层角膜移植术后的角膜生物力学特性。
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