利用蛋白质组学方法揭示 ACE 抑制剂的神经保护作用：对阿尔茨海默病治疗的启示。
Utilizing Proteomic Approaches to Uncover the Neuroprotective Effects of ACE Inhibitors: Implications for Alzheimer's Disease Treatment.
机构信息
Division of General & Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
出版信息
Molecules. 2023 Aug 8;28(16):5938. doi: 10.3390/molecules28165938.
Two types of angiotensin-converting enzyme (ACE) inhibitors, lisinopril and benazepril HCl, were tested in neuroblastoma cells and found to upregulate low-density lipoprotein-receptor-related protein 1B (LRP1B) and 14-3-3 protein zeta/delta. Additionally, benazepril HCl was found to increase the expression of calreticulin. The upregulation of these proteins by ACE inhibitors may contribute to the amelioration of cognitive deficits in Alzheimer's disease/dementia, as well as the clinically observed deceleration of functional decline in Alzheimer's patients. This discovery suggests that the supplementation of ACE inhibitors may promote neuronal cell survival independently of their antihypertensive effect. Overall, these findings indicate that ACE inhibitors may be a promising avenue for developing effective treatments for Alzheimer's disease.
两种血管紧张素转化酶（ACE）抑制剂，赖诺普利和盐酸贝那普利，在神经母细胞瘤细胞中进行了测试，结果发现它们能上调低密度脂蛋白受体相关蛋白 1B（LRP1B）和 14-3-3 蛋白 ζ/δ。此外，还发现盐酸贝那普利能增加钙网蛋白的表达。ACE 抑制剂对这些蛋白的上调可能有助于改善阿尔茨海默病/痴呆症的认知缺陷，以及临床上观察到的阿尔茨海默病患者功能衰退的减缓。这一发现表明，ACE 抑制剂的补充可能会促进神经元细胞的存活，而不依赖于其降压作用。总的来说，这些发现表明，ACE 抑制剂可能是开发阿尔茨海默病有效治疗方法的一个有前途的途径。
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