Malaník Milan, Čulenová Marie, Sychrová Alice, Skiba Adrianna, Skalicka-Woźniak Krystyna, Šmejkal Karel
Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackého 1946/1, 61200 Brno, Czech Republic.
Department of Natural Products Chemistry, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki Str., 20-093 Lublin, Poland.
Pharmaceuticals (Basel). 2023 Jul 26;16(8):1061. doi: 10.3390/ph16081061.
Epilepsy is a neurological disease characterized by recurrent seizures that can lead to uncontrollable muscle twitching, changes in sensitivity to sensory perceptions, and disorders of consciousness. Although modern medicine has effective antiepileptic drugs, the need for accessible and cost-effective medication is urgent, and products derived from plants could offer a solution. For this review, we have focused on natural compounds that have shown anticonvulsant activity in in vivo models of epilepsy at relevant doses. In some cases, the effects have been confirmed by clinical data. The results of our search are summarized in tables according to their molecular targets. We have critically evaluated the data we present, identified the most promising therapeutic candidates, and discussed these in the text. Their perspectives are supported by both pharmacokinetic properties and potential interactions. This review is intended to serve as a basis for future research into epilepsy and related disorders.
癫痫是一种神经系统疾病，其特征是反复发作的癫痫发作，可导致无法控制的肌肉抽搐、感觉感知敏感性的变化以及意识障碍。尽管现代医学有有效的抗癫痫药物，但迫切需要可及且经济高效的药物，而植物衍生产品可能提供一种解决方案。在本次综述中，我们重点关注了在癫痫体内模型中相关剂量下显示出抗惊厥活性的天然化合物。在某些情况下，这些作用已得到临床数据的证实。我们搜索的结果根据其分子靶点总结在表格中。我们对所呈现的数据进行了批判性评估，确定了最有前景的治疗候选物，并在文中进行了讨论。它们的前景得到了药代动力学特性和潜在相互作用的支持。本综述旨在作为未来癫痫及相关疾病研究的基础。
