Raslan Mohamed A, Raslan Sara A, Shehata Eslam M, Mahmoud Amr S, Lundstrom Kenneth, Barh Debmalya, Azevedo Vasco, Sabri Nagwa A
Drug Research Centre, Cairo P.O. Box 11799, Egypt.
Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo P.O. Box 11566, Egypt.
Pharmaceuticals (Basel). 2023 Aug 1;16(8):1093. doi: 10.3390/ph16081093.
Nutrigenomics is the study of the impact of diets or nutrients on gene expression and phenotypes using high-throughput technologies such as transcriptomics, proteomics, metabolomics, etc. The bioactive components of diets and nutrients, as an environmental factor, transmit information through altered gene expression and hence the overall function and traits of the organism. Dietary components and nutrients not only serve as a source of energy but also, through their interactions with genes, regulate gut microbiome composition, the production of metabolites, various biological processes, and finally, health and disease. Antimicrobial resistance in pathogenic and probiotic microorganisms has emerged as a major public health concern due to the presence of antimicrobial resistance genes in various food products. Recent evidence suggests a correlation between the regulation of genes and two-component and other signaling systems that drive antibiotic resistance in response to diets and nutrients. Therefore, diets and nutrients may be alternatively used to overcome antibiotic resistance against novel antibiotics. However, little progress has been made in this direction. In this review, we discuss the possible implementations of nutrigenomics in antibiotic resistance against novel antibiotics.
营养基因组学是利用转录组学、蛋白质组学、代谢组学等高通量技术研究饮食或营养物质对基因表达和表型的影响。饮食和营养物质的生物活性成分作为一种环境因素，通过改变基因表达传递信息，进而影响生物体的整体功能和特征。饮食成分和营养物质不仅是能量来源，还通过与基因的相互作用，调节肠道微生物群组成、代谢物产生、各种生物过程，最终影响健康和疾病。由于各种食品中存在抗微生物抗性基因，致病性和益生菌微生物中的抗微生物抗性已成为一个主要的公共卫生问题。最近的证据表明，基因调控与驱动对饮食和营养物质产生抗生素抗性的双组分及其他信号系统之间存在关联。因此，饮食和营养物质可作为克服新型抗生素抗药性的替代手段。然而，在这方面进展甚微。在本综述中，我们讨论了营养基因组学在对抗新型抗生素抗药性方面的可能应用。
