Chuljerm Hataichanok, Paradee Narisara, Katekaew Dabudsawin, Nantachai Panaphat, Settakorn Kornvipa, Srichairatanakool Somdet, Koonyosying Pimpisid
School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Environmental-Occupational Health Sciences and Non Communicable Diseases Research Center, Research Institute for Health Sciences Chiang Mai University, Chiang Mai 50200, Thailand.
Plants (Basel). 2023 Aug 14;12(16):2936. doi: 10.3390/plants12162936.
Iron is essential for numerous biological processes; however, an iron imbalance can contribute to a number of diseases. An excess of iron can accumulate in the body and subsequently induce the production of reactive oxygen species (ROS), leading to oxidative tissue damage and organ dysfunction. The liver, a major iron storage site, is vulnerable to this iron-induced oxidative damage; however, this issue can be overcome by the chelation of excess iron. This study aimed to investigate the effect of 6-gingerol-rich ginger () extract on iron chelation, antioxidation, and hepatoprotective function in protecting against iron-induced oxidative liver cell injury. In experiments, 6-gingerol was confirmed to be a main bioactive component of the ginger extract and possessed free radical scavenging activity, decreasing ABTS and DPPH radical levels, and inhibiting AAPH-induced red blood cell hemolysis. Interestingly, the extract significantly reduced the levels of labile cellular iron (LCI), intracellular ROS, and lipid peroxidation products (TBARS) in iron-loaded human hepatoma (Huh7) cells. In conclusion, this work highlights the iron chelation property of 6-gingerol-rich ginger extract and its antioxidant activity, which could potentially protect the liver from iron-induced oxidative tissue damage.
铁对众多生物过程至关重要；然而，铁失衡会引发多种疾病。体内铁过量会蓄积，进而诱导活性氧（ROS）生成，导致氧化组织损伤和器官功能障碍。肝脏是主要的铁储存部位，易受这种铁诱导的氧化损伤影响；不过，通过螯合过量的铁可解决这一问题。本研究旨在探讨富含6-姜酚的生姜提取物在防止铁诱导的氧化肝细胞损伤方面的铁螯合、抗氧化及肝脏保护作用。实验中，证实6-姜酚是生姜提取物的主要生物活性成分，具有自由基清除活性，可降低ABTS和DPPH自由基水平，并抑制AAPH诱导的红细胞溶血。有趣的是，该提取物显著降低了铁负载的人肝癌（Huh7）细胞中不稳定细胞铁（LCI）、细胞内ROS和脂质过氧化产物（TBARS）的水平。总之，这项研究突出了富含6-姜酚的生姜提取物的铁螯合特性及其抗氧化活性，这可能潜在地保护肝脏免受铁诱导的氧化组织损伤。
