Rubenfeld M, Abramson D H, Ellsworth R M, Kitchin F D
Ophthalmology. 1986 Aug;93(8):1016-9. doi: 10.1016/s0161-6420(86)33629-7.
Retrospective analysis of 358 cases of retinoblastoma for correlation between age and intraocular stage at the time of diagnosis revealed: in both early and advanced stages of intraocular disease, bilateral retinoblastoma presents at an earlier age than does unilateral retinoblastoma; support for the Knudson "two-hit" hypothesis of retinoblastoma genetics, the existence of a positive family history for retinoblastoma does not guarantee an earlier age at diagnosis compared to sporadic disease; and for any age at diagnosis, unilateral or bilateral disease, Group V is the most common intraocular stage found.
对358例视网膜母细胞瘤病例进行回顾性分析，以研究诊断时年龄与眼内分期之间的相关性，结果显示：在眼内疾病的早期和晚期阶段，双侧视网膜母细胞瘤的发病年龄均早于单侧视网膜母细胞瘤；支持视网膜母细胞瘤遗传学的Knudson“两次打击”假说，与散发性疾病相比，存在视网膜母细胞瘤阳性家族史并不能保证诊断时年龄更早；对于任何诊断年龄、单侧或双侧疾病，V组是最常见的眼内分期。
