da Rocha-Bastos Ra, Araújo Jr, Silva Rs, Gil-da-Costa Mj, Brandão E, Farinha Nj, Falcão-Reis F, Dinah-Bragança T
Department of Ophthalmology, Hospital São João, Porto, Portugal.
Hematology and Oncology Unit, Pediatric Hospital, Hospital São João, Porto, Portugal.
Clin Ophthalmol. 2014 May 20;8:993-7. doi: 10.2147/OPTH.S59601. eCollection 2014.
To describe the experience of the Ophthalmology Department of Hospital São João (HSJ), a tertiary health care center in North Region, Portugal, in terms of the diagnosis, treatment, and follow-up of retinoblastoma.
This was a retrospective study of patients diagnosed with retinoblastoma in Hospital São João, between 1978 and 2012.
Fifty patients with retinoblastoma were evaluated in our institution between 1978 and 2012. Four patients were excluded due to loss of follow-up. Among the 46 retinoblastoma cases, 33 (71.7%) were unilateral and 13 (28.3%) bilateral, with a mean age at diagnosis of 22.19 months and 6.92 months, respectively (P<0.001). Leukocoria was the most common presenting sign (36.9%), followed by strabismus (19.6%), a combination of leukocoria and strabismus (8.7%), and buphthalmia (2.2%). Between 1978 and 1992, nine retinoblastoma cases were referred to our hospital, all of them unilateral, and, in each case, enucleation was performed, with or without salvage therapy. Between 1993 and 2012, 18 eyes with retinoblastoma were successfully managed with conservative treatment.
Demographic results were generally coincident with previous reports. It is crucial to screen leukocoria in pediatric practice, even in asymptomatic children. The outcome of retinoblastoma treatment in our hospital is similar to other series in developed countries.
描述葡萄牙北部地区三级医疗中心圣若昂医院眼科在视网膜母细胞瘤诊断、治疗及随访方面的经验。
这是一项对1978年至2012年间在圣若昂医院被诊断为视网膜母细胞瘤患者的回顾性研究。
1978年至2012年间，我院对50例视网膜母细胞瘤患者进行了评估。4例患者因失访被排除。在46例视网膜母细胞瘤病例中，33例（71.7%）为单侧，13例（28.3%）为双侧，诊断时的平均年龄分别为22.19个月和6.92个月（P<0.001）。白瞳症是最常见的症状（36.9%），其次是斜视（19.6%）、白瞳症与斜视并存（8.7%）以及牛眼（2.2%）。1978年至1992年间，9例视网膜母细胞瘤病例转诊至我院，均为单侧，每例均进行了眼球摘除术，有或没有挽救治疗。1993年至2012年间，18只患视网膜母细胞瘤的眼睛通过保守治疗成功治愈。
人口统计学结果与先前报告基本一致。在儿科实践中筛查白瞳症至关重要，即使是无症状儿童。我院视网膜母细胞瘤的治疗结果与发达国家的其他系列研究相似。
