Ellis G S, Pakalnis V A, Worley G, Green J A, Frothingham T E, Sturner R A, Walls K W
Ophthalmology. 1986 Aug;93(8):1032-7. doi: 10.1016/s0161-6420(86)33625-x.
We studied a cohort of 333 children in kindergarten to determine the prevalence of seropositivity to Toxocara canis, and to detect and measure chronic health effects that might be attributable to past infection. We found that 23.1% of the children had serologic evidence of infection (antibody titer greater than or equal to 1:32), assayed by means of an enzyme-linked immunosorbent assay. Black children were more frequently infested than white children, as were children of parents who did not graduate from high school. In a subsample of seropositive and seronegative children, we found associations between seropositivity and both pica and puppy ownership; we did not find differences in the symptoms and signs that occur in toxocaral visceral larva migrans nor differences in measures of growth and nutrition. No child had ocular toxocariasis although 31.8% (106) of the children had antibody titers greater than or equal to 1:16. In a population in which approximately 20 to 30% of the children show serologic evidence of Toxocara infestation, care must be taken in differentiating toxocariasis-like ophthalmic lesions, due to the potential for the coincidental occurrence of retinoblastoma in a child who is seropositive for the Toxocara parasite.
我们对333名幼儿园儿童进行了研究，以确定犬弓首蛔虫血清阳性率，并检测和衡量过去感染可能导致的慢性健康影响。我们发现，通过酶联免疫吸附测定法检测，23.1%的儿童有感染的血清学证据（抗体滴度大于或等于1:32）。黑人儿童比白人儿童更常受到感染，父母未高中毕业的儿童也是如此。在血清阳性和血清阴性儿童的一个子样本中，我们发现血清阳性与异食癖和养小狗之间存在关联；我们没有发现犬弓首线虫内脏幼虫移行所出现的症状和体征有差异，也没有发现生长和营养指标有差异。虽然31.8%（106名）的儿童抗体滴度大于或等于1:16，但没有儿童患有眼弓蛔虫病。在大约20%至30%的儿童有犬弓首蛔虫感染血清学证据的人群中，由于感染犬弓首蛔虫寄生虫血清阳性的儿童可能同时发生视网膜母细胞瘤，因此在鉴别类弓蛔虫病的眼部病变时必须谨慎。
