Jones W E, Schantz P M, Foreman K, Smith L K, Witte E J, Schooley D E, Juranek D D
Am J Dis Child. 1980 Oct;134(10):967-9. doi: 10.1001/archpedi.1980.02130220045014.
A questionnaire and serologic survey of a Pennsylvania community revealed that 23 (54%) of 43 study participants had antibody titers to Toxocara canis (enzyme-linked immunosorbent assay test [ELISA]) in the range defined as positive (greater than or equal to 1:32). Age-specific seropositivity rates were highest among adults (greater than or equal to 18 years). Positive titers ranged from 1:32 to 1:512. Seropositivity did not cluster by family, and seropositivity rates were significantly higher than those of a control group. Physical examination and laboratory tests designed to detect clinical signs of toxocariasis were performed on individuals with positive ELISA titers. Nine of 23 had a history of pica, seizures, or chronic pulmonary symptoms; however, physical examination revealed no abnormalities. Although medical examination and laboratory tests revealed a few abnormalities, neither the visceral larva migrans syndrome nor the ocular lesions characteristic of those produced by Toxocara sp were observed in any individual. We conclude that although certain populations may have high seropositivity rates to Toxocara antigens, indicating previous infection, clinical diseases may be uncommon.
对宾夕法尼亚州一个社区进行的问卷调查和血清学调查显示，43名研究参与者中有23人（54%）对犬弓首蛔虫的抗体滴度（酶联免疫吸附试验[ELISA]）处于定义为阳性的范围内（大于或等于1:32）。特定年龄的血清阳性率在成年人（大于或等于18岁）中最高。阳性滴度范围为1:32至1:512。血清阳性情况在家庭中没有聚集，且血清阳性率显著高于对照组。对ELISA滴度呈阳性的个体进行了旨在检测弓蛔虫病临床体征的体格检查和实验室检查。23人中有9人有异食癖、癫痫或慢性肺部症状史；然而，体格检查未发现异常。尽管医学检查和实验室检查发现了一些异常，但在任何个体中均未观察到内脏幼虫移行综合征或弓蛔虫属所致特征性眼部病变。我们得出结论，尽管某些人群对弓蛔虫抗原可能有较高的血清阳性率，表明既往感染，但临床疾病可能并不常见。
