Glickman L T, Schantz P M, Cypess R H
Trans R Soc Trop Med Hyg. 1979;73(3):254-8. doi: 10.1016/0035-9203(79)90077-4.
The enzyme-linked immunosorbent assay (ELISA) using Toxocara canis larva-specific antigens was used to confirm a presumptive clinical diagnosis of visceral larva migrans in patients whose serum specimens were submitted to the Center for Disease Control. The clinical and epidemiological characteristics of patients with diagnostic ELISA titres (greater than or equal to log2 5) were compared with patients who had less or no detectable antibody. The typical patient with serologically confirmed toxocaral visceral larva migrans was about five years of age and resided in the southern half of the USA. Clinical findings were likely to include leucocytosis, eosinophilia, an increased anti-A or anti-B isohaemagglutinin titre, and an elevated serum IgG level. Pica, as ascertained by a physician questionnaire, was not a consistent finding and both sexes were nearly equally represented.
采用犬弓首线虫幼虫特异性抗原的酶联免疫吸附测定（ELISA），对血清标本提交至疾病控制中心的患者进行内脏幼虫移行症的临床初步诊断确认。将诊断性ELISA滴度（大于或等于log2 5）患者的临床和流行病学特征与抗体检测较少或未检测到抗体的患者进行比较。血清学确诊的弓首线虫内脏幼虫移行症的典型患者约五岁，居住在美国南部地区。临床发现可能包括白细胞增多、嗜酸性粒细胞增多、抗A或抗B同种血凝素滴度升高以及血清IgG水平升高。通过医生问卷调查确定的异食癖并非一致的发现，男女比例几乎相等。
