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肝转移揭示阴茎黑色素瘤:病例报告

Hepatic Metastasis Revealing a Melanoma of the Penis: Case Report.

作者信息

Boui Meriem, Hammoune Nabil, Slioui Badr, Zouaki Zakaria, Atmane Mehdi, Mouhsine Abdelilah, Haouane Mohamed Amine, Azami Mohamed Amine, Kaakoua Mohamed, Assadi Ismail, Boui Mohammed, Bouhamidi Ahmed

机构信息

Department of Radiology, Avicenne Military Hospital, Cadi Ayyad University, Marrakech, Morocco.

Department of Anatomopathology, Avicenne Military Hospital, Cadi Ayyad University, Marrakech, Morocco.

出版信息

JMIR Dermatol. 2022 Sep 27;5(3):e37400. doi: 10.2196/37400.

DOI:10.2196/37400
PMID:37632880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10334924/
Abstract

Melanoma of the penis is a rare tumor with a poor prognosis. We report the case of a 73-year-old patient with no significant medical history, admitted for deterioration of the general condition and bilateral inguinal lymph nodes. An abdominal ultrasound and thoraco-abdomino-pelvic CT (computed tomography) scan revealed metastatic liver nodules, the tumoral nature of which was confirmed by an anatomopathological examination. Further clinical examination revealed papular and ulcerated lesions of the penis located at the urethral meatus and glans penis. These lesions were biopsied and histologically assessed as melanoma. The contribution of imaging in penile tumors is generally not useful for diagnosis as clinical examination is key. However, it has its place in the assessment of locoregional and distant extension. In our case, it was the distant lesions that helped orient the diagnosis. The patient underwent immunotherapical treatment and is still alive 19 months after the diagnosis.

摘要

阴茎黑色素瘤是一种罕见的肿瘤,预后较差。我们报告一例73岁患者,无重大病史,因全身状况恶化及双侧腹股沟淋巴结肿大入院。腹部超声和胸腹部盆腔CT扫描显示肝脏有转移性结节,经解剖病理学检查证实其肿瘤性质。进一步临床检查发现阴茎尿道口和龟头有丘疹及溃疡病变。对这些病变进行活检并经组织学评估为黑色素瘤。影像学检查对阴茎肿瘤的诊断一般没有帮助,因为临床检查是关键。然而,它在评估局部和远处转移方面有其作用。在我们的病例中,是远处病变有助于明确诊断。该患者接受了免疫治疗,诊断后19个月仍然存活。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/95bab5f91d7c/derma_v5i3e37400_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/88fa5690428d/derma_v5i3e37400_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/00526c8a0181/derma_v5i3e37400_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/17c615c95fed/derma_v5i3e37400_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/262d45271f40/derma_v5i3e37400_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/d1d44f07f560/derma_v5i3e37400_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/fd17eb795420/derma_v5i3e37400_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/95bab5f91d7c/derma_v5i3e37400_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/88fa5690428d/derma_v5i3e37400_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/00526c8a0181/derma_v5i3e37400_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/17c615c95fed/derma_v5i3e37400_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/262d45271f40/derma_v5i3e37400_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/d1d44f07f560/derma_v5i3e37400_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/fd17eb795420/derma_v5i3e37400_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74d9/10334924/95bab5f91d7c/derma_v5i3e37400_fig7.jpg

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本文引用的文献

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Melanoma in situ of penis: a very rare entity: A case report and review of the literature.阴茎原位黑色素瘤:一种极为罕见的病症:病例报告及文献综述
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Malignant melanoma of the penis and urethra: one case report.
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World J Surg Oncol. 2014 Nov 11;12:340. doi: 10.1186/1477-7819-12-340.
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Melanoma of the glans penis successfully treated with topical imiquimod: dermoscopy usefulness in clinical monitoring and review of the literature.外用咪喹莫特成功治疗阴茎头黑色素瘤:皮肤镜在临床监测中的作用及文献复习
G Ital Dermatol Venereol. 2017 Dec;152(6):663-668. doi: 10.23736/S0392-0488.16.04789-1. Epub 2014 Sep 18.
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Penile primary melanoma: analysis of 6 patients treated at Brazilian National Cancer Institute in the last eight years.阴茎原发性黑色素瘤:巴西国家癌症研究所近 8 年来治疗的 6 例患者分析。
Int Braz J Urol. 2013 Nov-Dec;39(6):823-31. doi: 10.1590/S1677-5538.IBJU.2013.06.08.
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Melanoma of the glans penis and urethra.阴茎龟头和尿道的黑色素瘤。
Urology. 2014 Jan;83(1):6-11. doi: 10.1016/j.urology.2013.07.009. Epub 2013 Aug 23.
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Primary malignant melanoma of the penis: a case report.阴茎原发性恶性黑色素瘤 1 例报告。
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