Center for Vital Longevity and School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Center for Vital Longevity and School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA.
Neurobiol Aging. 2023 Nov;131:132-143. doi: 10.1016/j.neurobiolaging.2023.07.001. Epub 2023 Jul 11.
Prior functional magnetic resonance imaging findings in young adults indicate that recollection-sensitive neural regions dissociate according to the time courses of their respective recollection effects. Here, we examined whether such dissociations are also evident in older adults. Young and older participants encoded a series of word-image pairs, judging which of the denoted objects was the smaller. At the test, participants judged whether each of a series of test words was old or new. If a word was old, the requirement was to recall the associated image and maintain it over a variable delay period. Older adults demonstrated significantly lower associative memory performance than young adults. Transient recollection effects were identified in the left hippocampus, medial prefrontal cortex, and posterior cingulate, while sustained effects were widespread across left lateral cortex and were also evident in the bilateral striatum. Except for those in the left insula, all effects were age-invariant. These findings suggest that both transient and sustained recollection effects are largely stable across much of the healthy adult life span.
先前的功能磁共振成像研究结果表明，在年轻人中，根据各自回忆效应的时间进程，与回忆敏感相关的神经区域会分离。在这里，我们研究了这种分离在老年人中是否也存在。年轻和年长的参与者编码了一系列单词-图像对，判断所表示的物体中哪个更小。在测试中，参与者判断一系列测试单词中的每一个是旧的还是新的。如果一个单词是旧的，则要求回忆相关的图像，并在可变的延迟期间保持它。与年轻人相比，老年人的联想记忆表现明显较差。在左侧海马体、内侧前额叶皮层和后扣带回中发现了短暂的回忆效应，而持续的效应则广泛分布在左侧外侧皮层，并且在双侧纹状体中也很明显。除了左侧脑岛外，所有的效应在年龄上都是不变的。这些发现表明，在健康的成年期，无论是短暂的还是持续的回忆效应在很大程度上都是稳定的。
