Department of Toxicology, School of Public Health; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, China; Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Toxicology, School of Public Health; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei, China.
Chemosphere. 2023 Nov;340:139964. doi: 10.1016/j.chemosphere.2023.139964. Epub 2023 Aug 24.
Early life in utero exposure to per- and polyfluoroalkyl substances (PFASs) and infiltration through the placenta into cord blood pose significant risk to fetal development. Accumulating knowledge suggests that PFASs pass through the placenta in multiple transportation ways, not limiting to passive transport but also active transport or facilitated diffusion. Therefore, we propose that the transplacental transfer efficiency (TTE) could be re-evaluated as traditional cord to maternal ratio-based method might overlook certain biological or health information from the mother and fetus. In this study, we investigated 30 PFAS chemicals in paired maternal and cord serum from 195 births classified as small-for-gestational-age (SGA) and matched appropriate-for-gestational-age (AGA). PFASs were ubiquitously detected in the maternal and serum samples, with PFOA, PFOS, 6:2 Cl-PFESA and other dominant compounds. We adopted a modified TTE estimation method (TTE), taking into consideration of the total burden mass of PFASs in the blood from mother to fetus. Using the modified TTE, a significant (p < 0.05) decrease was observed in the PFAS transplacental transfer potential in SGA (1.6%-11.3%) compared to AGA (2.3%-21.1%), suggesting a reverse association between TTE and SGA birth risk. This is the first study attempted to re-evaluate the TTE of PFAS and indicates that TTE might be more advantageous to reflect the transplacental transfer potency of chemicals particularly when transportation mechanisms are multi-faceted.
在子宫内早期接触全氟和多氟烷基物质 (PFAS) 并通过胎盘渗透到脐带血中，对胎儿发育构成重大风险。越来越多的知识表明，PFAS 可以通过多种转运方式穿过胎盘，不仅限于被动转运，还包括主动转运或易化扩散。因此，我们提出，胎盘转运效率 (TTE) 可以重新评估，因为基于传统脐带与母体比值的方法可能会忽略来自母亲和胎儿的某些生物学或健康信息。在这项研究中，我们调查了 195 例出生时被归类为小于胎龄儿 (SGA) 的母婴配对血清中的 30 种 PFAS 化学物质，并匹配了适当胎龄儿 (AGA)。PFAS 在母体和血清样本中普遍存在，其中 PFOA、PFOS、6:2 Cl-PFESA 和其他主要化合物。我们采用了一种改良的 TTE 估计方法 (TTE)，考虑了母体到胎儿血液中 PFAS 总负担质量。使用改良的 TTE，与 AGA（2.3%-21.1%）相比，SGA（1.6%-11.3%）中 PFAS 胎盘转运潜力显著降低（p<0.05），表明 TTE 与 SGA 出生风险之间存在反向关联。这是首次尝试重新评估 PFAS 的 TTE，并表明 TTE 可能更有利于反映化学物质的胎盘转运能力，特别是当转运机制是多方面的。
