MOE and Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.
Department of Neonatology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Environ Sci Pollut Res Int. 2019 Jan;26(3):2691-2698. doi: 10.1007/s11356-018-3686-3. Epub 2018 Nov 27.
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) can be transferred from a mother to her fetus during pregnancy and adversely affect fetal development. However, the efficiency and influencing factors of PFASs maternal-fetal transfer remain unclear. We measured the levels of six perfluoroalkylcarboxylates, three perfluoroalkylsulfonates, and one sulfonamide in 369 pairs of maternal and umbilical cord serum and examined the transplacental transfer efficiency (TTE) of PFASs by the functional group and carbon chain length in a prospective birth cohort in Shandong, China. All ten PFASs were detected in both maternal and umbilical cord serum in nearly all samples. Maternal and cord levels were closely correlated (the correlation coefficient [r] ranging from 0.485 to 0.908) in most PFASs except perfluorobutane sulfonic acid (PFBS) (r = 0.159). TTE was significantly affected by the functional group and carbon chain length. Compared to perfluoroalkylcarboxylates, perfluoroalkylsulfonates had a lower ratio of maternal to fetal transfer. A U-shaped relationship between carbon chain length and TTE was observed for perfluoroalkylcarboxylates while a monotonic descending trend was identified between TTE and the increasing carbon chain length for perfluoroalkylsulfonates. PFASs can readily pass through the placenta. The functional group and carbon chain length are important determinants for the TTE of PFASs.
全氟烷基和多氟烷基物质（PFASs）可在妊娠期间从母体转移到胎儿体内，并对胎儿发育产生不利影响。然而，PFASs 从母体向胎儿转移的效率及其影响因素仍不清楚。我们在中国山东的一个前瞻性出生队列中测量了 369 对母血和脐血中的 6 种全氟烷基羧酸、3 种全氟烷基磺酸盐和 1 种磺酰胺水平，并通过官能团和碳链长度检查了 PFASs 的胎盘转移效率（TTE）。所有十种 PFASs 在几乎所有样本中均在母血和脐血中被检测到。除全氟丁烷磺酸（PFBS）外（r=0.159），大多数 PFASs 的母血和脐血水平密切相关（相关系数[r]范围为 0.485 至 0.908）。TTE 明显受到官能团和碳链长度的影响。与全氟烷基羧酸相比，全氟烷基磺酸盐的母体向胎儿转移比例较低。全氟烷基羧酸的碳链长度与 TTE 之间呈 U 形关系，而全氟烷基磺酸盐的 TTE 与碳链长度的增加呈单调递减趋势。PFASs 可以轻易穿过胎盘。官能团和碳链长度是决定 PFASs TTE 的重要因素。
