Emergency Center, Hubei Clinical Research Center for Emergency and Resuscitation, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Emergency Department, Xiantao First People's Hospital Affiliated to Changjiang University, Xiantao, China.
Eur J Clin Nutr. 2023 Dec;77(12):1160-1166. doi: 10.1038/s41430-023-01336-1. Epub 2023 Aug 26.
Whether there is an association between dietary choline intake and non-alcoholic fatty liver disease (NAFLD) in American adults remains unclear.
Data came from the National Health and Nutrition Examination Survey 2017-2018. Choline intake was defined by the mean amounts of two 24 h dietary recalls, and choline intake was categorized into three groups according to the quartiles: inadequate (<P), average (P-P), and optimal (>P). Hepatic steatosis was assessed with FibroScan, in which VCTE was employed with controlled attenuation to derive the controlled attenuation parameter (CAP), and NAFLD was defined as a CAP score ≥285 dB/m. Multivariable linear regression was performed to assess the linear relationship between choline intake and CAP. Multivariable logistics regression models were conducted to assess the association between choline intake status and NAFLD in the final sample and subgroup analysis was then performed in men and women.
The amount of dietary choline was inversely associated with CAP score (β = -0.262, 95% CI: -0.280, -0.245). Compared to inadequate choline intake, optimal choline intake was related to a lower risk of NAFLD (OR: 0.705, 95% CI: 0.704-0.706) in the final sample. Subgroup analysis by gender revealed that the highest choline intake status was associated with a lower risk of NAFLD both in females (OR: 0.764, 95% CI: 0.762-0.766), and males (OR: 0.955, 95% CI: 0.953-0.958) when compared to the lowest choline intake.
With the latest NHANES data, we found that higher dietary choline was associated with a lower risk of NAFLD in American adults, and such a relationship exists in both females and males.
美国成年人的膳食胆碱摄入量与非酒精性脂肪肝（NAFLD）之间是否存在关联尚不清楚。
数据来自 2017-2018 年全国健康和营养调查。胆碱摄入量由两次 24 小时膳食回忆的平均值定义，根据四分位数将胆碱摄入量分为三组：不足（<P）、平均（P-P）和充足（>P）。肝脂肪变性采用 FibroScan 评估，其中 VCTE 采用受控衰减技术衍生受控衰减参数（CAP），NAFLD 定义为 CAP 评分≥285dB/m。采用多元线性回归分析胆碱摄入量与 CAP 之间的线性关系。采用多变量逻辑回归模型在最终样本中评估胆碱摄入量状况与 NAFLD 的关系，然后在男性和女性中进行亚组分析。
膳食胆碱的摄入量与 CAP 评分呈负相关（β=-0.262，95%CI：-0.280，-0.245）。与胆碱摄入不足相比，胆碱摄入充足与 NAFLD 的风险降低相关（OR：0.705，95%CI：0.704-0.706）。按性别进行的亚组分析显示，与最低胆碱摄入量相比，最高胆碱摄入量状况与女性（OR：0.764，95%CI：0.762-0.766）和男性（OR：0.955，95%CI：0.953-0.958）的 NAFLD 风险降低相关。
使用最新的 NHANES 数据，我们发现美国成年人较高的膳食胆碱摄入量与较低的 NAFLD 风险相关，这种关系在女性和男性中均存在。
