布洛芬与酮咯酸在控制肾绞痛疼痛方面的比较：一项随机对照研究的荟萃分析。
Comparison of Ibuprofen with Ketorolac on the Control of Renal Colic Pain: A Meta-Analysis of Randomized Controlled Studies.
机构信息
Department of Urology, Mianyang Central Hospital, China.
出版信息
Urol J. 2023 Dec 26;20(6):379-384. doi: 10.22037/uj.v20i.7572.
PURPOSE
The comparison of ibuprofen with ketorolac remains controversial for the pain control of renal colic. We therefore conduct this meta-analysis to compare the analgesic efficacy of ibuprofen with ketorolac for renal colic.
METHODS
We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through December 2022 for randomized controlled trials (RCTs) assessing the analgesic efficacy of ibuprofen in comparison with ketorolac for renal colic. This meta-analysis was performed using the random-effect or fixed-effect model based on the heterogeneity.
RESULTS
Four RCTs were included in the meta-analysis. In patients with renal colic pain, intravenous ibuprofen and ketorolac produced comparable pain scores at 15 min (MD = -0.46; 95% CI = -1.24 to 0.31; P = 0.24), 30 min (MD = -0.81; 95% CI = -1.75 to 0.31; P = 0.09), 60 min (MD=-0.63; 95% CI = -1.40 to 0.13; P = 0.10) and 120 min (MD = -0.74; 95% CI = -2.18 to 0.70; P = 0.31), as well as adverse events (OR = 0.95; 95% CI = 0.61 to 1.49; P = 0.83).
CONCLUSION
Ibuprofen can obtain comparable analgesic efficacy to ketorolac for renal colic pain.
目的
布洛芬与酮咯酸在肾绞痛的疼痛控制方面的比较仍存在争议。因此，我们进行这项荟萃分析，以比较布洛芬与酮咯酸治疗肾绞痛的镇痛效果。
方法
我们检索了 PubMed、EMbase、Web of science、EBSCO 和 Cochrane 图书馆数据库，截至 2022 年 12 月，以评估布洛芬与酮咯酸治疗肾绞痛的镇痛效果的随机对照试验（RCT）。本荟萃分析根据异质性采用随机效应或固定效应模型进行。
结果
共有 4 项 RCT 纳入荟萃分析。在肾绞痛疼痛患者中，静脉注射布洛芬和酮咯酸在 15 分钟（MD=-0.46；95%CI=-1.24 至 0.31；P=0.24）、30 分钟（MD=-0.81；95%CI=-1.75 至 0.31；P=0.09）、60 分钟（MD=-0.63；95%CI=-1.40 至 0.13；P=0.10）和 120 分钟（MD=-0.74；95%CI=-2.18 至 0.70；P=0.31）时产生的疼痛评分相似，以及不良事件（OR=0.95；95%CI=0.61 至 1.49；P=0.83）。
结论
布洛芬在肾绞痛疼痛方面可获得与酮咯酸相当的镇痛效果。
Zotero 插件