酮咯酸添加治疗肾绞痛疼痛的镇痛效果：一项随机对照研究的荟萃分析。
The analgesic effect of ketorolac addition for renal colic pain: A meta-analysis of randomized controlled studies.
机构信息
Department of Urinary Surgery, Xiantao first people's Hospital Affiliated to Yangtze University, PR China.
Department of Urinary Surgery, Xiantao first people's Hospital Affiliated to Yangtze University, PR China.
出版信息
Am J Emerg Med. 2021 May;43:12-16. doi: 10.1016/j.ajem.2020.12.073. Epub 2020 Dec 30.
INTRODUCTION
The effect of ketorolac addition for the pain control of renal colic remains controversial. We conduct a systematic review and meta-analysis to explore the analgesic efficacy of ketorolac addition for renal colic.
METHODS
We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through September 2020 for randomized controlled trials (RCTs) assessing the analgesic efficacy of ketorolac addition for renal colic. This meta-analysis is performed using the random-effect model.
RESULTS
Four RCTs are included in the meta-analysis. In patients with renal colic pain, ketorolac addition is associated with significantly lower pain scores at 10-20 min (SMD=-2.50; 95% CI=-4.31 to -0.68; P=0.007) and analgesic rescue (RR=0.68; 95% CI=0.52 to 0.89; P=0.006), but reveals no notable effect on nausea (RR=0.36; 95% CI=0.12 to 1.12; P=0.08), vomiting (RR=0.50; 95% CI=0.13 to 1.95; P=0.31), or dizziness (RR=0.68; 95% CI=0.05 to 0.60; P=0.007).
CONCLUSIONS
Ketorolac addition may improve the analgesic efficacy for renal colic pain.
简介
关于酮咯酸在控制肾绞痛疼痛方面的作用仍然存在争议。我们进行了一项系统评价和荟萃分析，以探讨酮咯酸对肾绞痛的镇痛效果。
方法
我们通过检索 PubMed、EMbase、Web of Science、EBSCO 和 Cochrane 图书馆数据库，检索了截至 2020 年 9 月评估酮咯酸对肾绞痛镇痛效果的随机对照试验（RCT）。这项荟萃分析采用随机效应模型进行。
结果
荟萃分析纳入了 4 项 RCT。对于肾绞痛疼痛的患者，酮咯酸的加入与 10-20 分钟时的疼痛评分显著降低相关（SMD=-2.50；95%CI=-4.31 至-0.68；P=0.007）和镇痛救援（RR=0.68；95%CI=0.52 至 0.89；P=0.006），但对恶心（RR=0.36；95%CI=0.12 至 1.12；P=0.08）、呕吐（RR=0.50；95%CI=0.13 至 1.95；P=0.31）或头晕（RR=0.68；95%CI=0.05 至 0.60；P=0.007）没有显著影响。
结论
酮咯酸的加入可能会提高肾绞痛疼痛的镇痛效果。
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