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临床、放射影像学和组织病理学特征可区分色素性丛状神经纤维瘤与先天性黑素细胞痣。

Clinical, Radiologic, and Histopathologic Features that Distinguish a Pigmented Plexiform Neurofibroma from a Congenital Melanocytic Nevus.

机构信息

Cooper Medical School of Rowan University, Camden, NJ.

Division of Dermatology, Cooper University Hospital, Camden, NJ.

出版信息

Skinmed. 2023 Aug 28;21(3):187-189. eCollection 2023.

PMID:37634103
Abstract

A 13-year-old Hispanic boy with no significant medical etymology presented with a chief complaint of widespread brown macules and patches. He had a large and evenly pigmented brown patch, with a centrally located 2.2 cm × 1.2 cm soft and darkly pigmented plaque, which became more apparent with tension applied to the surrounding skin (Figure 1). The patient's mother stated that the plaque was present since birth and had increased in size over time. The clinical differential diagnoses included a congenital melanocytic nevus (CMN), a large café au lait macule (CALM), and a Becker's nevus with a congenital smooth muscle hamartoma.

摘要

一位 13 岁的西班牙裔男孩,无明显医学病因,主要抱怨全身广泛出现棕色斑片和斑块。他有一个大而均匀着色的棕色斑块,中央有一个 2.2 厘米×1.2 厘米的柔软、色素沉着深的斑块,当周围皮肤拉紧时,斑块变得更加明显(图 1)。患者的母亲说,斑块出生时就存在,并且随着时间的推移而增大。临床鉴别诊断包括先天性黑素细胞痣(CMN)、大咖啡牛奶斑(CALM)和伴有先天性平滑肌错构瘤的 Becker 痣。

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1
Clinical, Radiologic, and Histopathologic Features that Distinguish a Pigmented Plexiform Neurofibroma from a Congenital Melanocytic Nevus.临床、放射影像学和组织病理学特征可区分色素性丛状神经纤维瘤与先天性黑素细胞痣。
Skinmed. 2023 Aug 28;21(3):187-189. eCollection 2023.
2
Genetic analyses of mosaic neurofibromatosis type 1 with giant café-au-lait macule, plexiform neurofibroma and multiple melanocytic nevi.巨牛奶咖啡斑、丛状神经纤维瘤和多发性黑色素痣的神经纤维瘤病 1 型嵌合体的遗传学分析。
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Congenital smooth muscle hamartoma: the importance of differentiation from melanocytic nevi.先天性平滑肌错构瘤:与黑素细胞痣鉴别诊断的重要性
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Pigmented plexiform neurofibroma: Distinction from a large congenital melanocytic nevus.色素性丛状神经纤维瘤:与巨大先天性黑素细胞痣的鉴别。
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Port-wine-stain (nevus flammeus), congenital Becker's nevus, café-au-lait-macule and lentigines: phakomatosis pigmentovascularis type Ia--a new combination.葡萄酒色斑(鲜红斑痣)、先天性贝克痣、咖啡斑和雀斑:Ia型色素血管性斑痣性错构瘤病——一种新的组合。
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Studies on café au lait spots in neurofibromatosis and pigmented macules of nevus spilus.神经纤维瘤病中咖啡斑及斑痣性色素沉着斑的研究。
Tohoku J Exp Med. 1976 Mar;118(3):255-73.