Department of Ultrasound, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China.
Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, China.
Colloids Surf B Biointerfaces. 2023 Oct;230:113523. doi: 10.1016/j.colsurfb.2023.113523. Epub 2023 Aug 22.
Polyetheretherketone (PEEK) is being increasingly recognized as a highly promising polymer implant in orthopaedics due to its advantageous biocompatibility, favorable processability, and radiation resistance. Nonetheless, the long-term application of PEEK implants in vivo faces challenges due to unfavorable post-implantation inflammatory and immune reactions, which result in suboptimal osseointegration rates. Hence, biofunctionalizing the surface of PEEK implants emerges as a viable strategy to enhance osseointegration and increase the success rate. In this study, we developed a multifunctional PEEK implant through the in-situ incorporation of chitosan-coated bioactive glass nanoparticles (BGNs). This approach can impart immunomodulatory properties and enhance the potential for osseointegration. The resulting biofunctionalized PEEK material exhibited multiple beneficial effects. For instance, it facilitated M2 phenotypic polarization of macrophages, diminished the expression of inflammatory factors, and enhanced the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) in vitro. Moreover, it exhibited an improved capacity for osseointegration when tested in vivo. The findings of the experiment highlighted the pivotal and complex role of the biofunctionalized PEEK implant in maintaining typical bone immunity and metabolism. The study proposes that the application of chitosan-BGNs presents a straightforward approach to developing multifunctional implants with the ability to promote biomineralization and immunomodulation, specifically tailored for orthopaedic applications.
聚醚醚酮（PEEK）因其良好的生物相容性、优异的加工性能和抗辐射性，正逐渐被认为是一种极具前景的骨科用聚合物植入物。然而，PEEK 植入物在体内的长期应用面临着挑战，因为植入后的炎症和免疫反应不佳，导致骨整合率不理想。因此，对 PEEK 植入物表面进行生物功能化是提高骨整合和增加成功率的可行策略。在本研究中，我们通过原位掺入壳聚糖包覆的生物活性玻璃纳米颗粒（BGNs）开发了一种多功能 PEEK 植入物。这种方法可以赋予免疫调节特性并增强骨整合的潜力。所得的生物功能化 PEEK 材料表现出多种有益的效果。例如，它促进了巨噬细胞的 M2 表型极化，降低了炎症因子的表达，并增强了骨髓间充质干细胞（BMSCs）的体外成骨分化。此外，在体内试验中，它表现出了更好的骨整合能力。实验结果强调了生物功能化 PEEK 植入物在维持典型骨免疫和代谢方面的关键和复杂作用。该研究提出，壳聚糖-BGNs 的应用为开发具有促进生物矿化和免疫调节功能的多功能植入物提供了一种简单的方法，特别适用于骨科应用。
